- Associations between ApoB/ApoA-I Ratios and Metabolic Syndrome and its Components in Patients with Type 2 Diabetes.
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Jung Eun Kim, Wha Young Kim, Yoon Jung Lee, Ji Eun Park, Young Ju Choi, Kap Bum Huh, Ji Yun Hwang
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Korean Diabetes J. 2009;33(2):143-154. Published online April 1, 2009
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DOI: https://doi.org/10.4093/kdj.2009.33.2.143
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- BACKGROUND
The Apolipoprotein B/apolipoprotein A-I ratio (apoB/apoA-I) is a powerful clinical indicator of metabolic syndrome. However, few studies have searched for an association between ApoB/ApoA-I and metabolic syndrome in Korean patients with type 2 diabetes. We investigated the relation between ApoB/ApoA-I and the risk of metabolic syndrome and its components. METHODS: Subjects were 812 (424 males and 388 females) Korean patients who were being treated for type 2 diabetes at Huh's Diabetes Center in Seoul. The patients were classified into quartiles (lowest:Q1-highest:Q4) of ApoB/ApoA-I by gender. Anthropometric and hematological characteristics and dietary intake using a food frequency questionnaire were assessed. RESULTS: The prevalence of metabolic syndrome in our sample was 47.9% in males and 66.5% in females. The odds ratios (OR) for metabolic syndrome and for having its components were significantly increased from Q2 to Q4 quartiles of ApoB/ApoA-I in males (OR = 5.37; 95% CI = 2.98-9.65 and OR = 7.41; 95% CI = 4.04-13.6) and females (OR = 2.57; 95% CI = 1.28-5.15 and OR = 8.49; 95% CI = 4.28-16.8). These trends withstood adjustment for age, duration of type 2 diabetes, fasting blood glucose levels, and macronutrient intake both in males (OR = 5.24; 95% CI = 2.80-9.24 and OR = 7.98; 95% CI = 4.09-15.6) and in females (OR=4.41; 95% CI = 2.26-8.61 and OR = 8.29; 95% CI = 3.85-17.8). CONCLUSION: ApoB/ApoA-I appeared to be independently associated with risk of having metabolic syndrome and its components in Korean patients with type 2 diabetes after adjustment for putative risk factors including macronutrient intake, a particularly important lifestyle factor for patients with type 2 diabetes. A follow-up study of this population should evaluate the mechanisms underlying the relation between ApoB/ApoA-I and metabolic syndrome and its components.
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Citations
Citations to this article as recorded by  - Association between dietary flavanones intake and lipid profiles according to the presence of metabolic syndrome in Korean women with type 2 diabetes mellitus
Ji Soo Oh, Hyesook Kim, Aswathy Vijayakumar, Oran Kwon, Young Ju Choi, Kap Bum Huh, Namsoo Chang
Nutrition Research and Practice.2016; 10(1): 67. CrossRef - Hepatoprotective Effects of Soybean Embryo by Enhancing Adiponectin-Mediated AMP-Activated Protein KinaseαPathway in High-Fat and High-Cholesterol Diet-Induced Nonalcoholic Fatty Liver Disease
Jihye Hong, Sera Kim, Hyun-Sook Kim
Journal of Medicinal Food.2016; 19(6): 549. CrossRef - The Relationship between Factors of Metabolic Syndrome in Korean Adult Males and the Parents' Family History of Diabetes
Hyung-Su Park, Jin-Gyu Jeong, Jin-Ho Yu
The Journal of the Korea institute of electronic communication sciences.2013; 8(5): 779. CrossRef
- The Association of Plasma HDL-Cholesterol Level with Cardiovascular Disease Related Factors in Korean Type 2 Diabetic Patients.
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Hye Sook Hong, Jong Suk Park, Han Kyoung Ryu, Wha Young Kim
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Korean Diabetes J. 2008;32(3):215-223. Published online June 1, 2008
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DOI: https://doi.org/10.4093/kdj.2008.32.3.215
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2,768
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38
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Abstract
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- BACKGROUND
Cardiovascular disease (CVD) is the major cause of death in type 2 diabetic patients. The purpose of this study was to investigate the characteristics of Korean type 2 diabetes mellitus (DM) patients according to plasma high density lipoprotein (HDL) cholesterol level and to document the effect of diet on HDL-cholesterol. METHODS: The subjects were 252 (male: 134, female: 118) Korean type 2 DM patients recruited from a general hospital's DM clinic and divided into low HDL-cholesterol group (male < 40 mg/dL, female < 50 mg/dL) and control group (male > or = 40 mg/dL, female > or = 50 mg/dL). Anthropometric and hematological variables and dietary intake were assessed by the groups. RESULTS: The subject's mean age was 60.2 +/- 1.1 years and duration of diabetes was 9.5 +/- 1.0 years. Anthropometric measurements (body fat mass, % body fat, WHR, fat free mass, and muscle mass) and BMI were not significantly different between two groups. The male subjects with low HDL-cholesterolemia showed higher Atherogenic Index (AI, P < 0.001) and higher % carbohydrate from energy than control group (P < 0.01). The female subjects with low HDL-cholesterolemia showed higher AI (P < 0.001) and a tendency of higher triglyceride level and lower intake of energy, protein, lipid, vitamin B1 and vitamin E (P < 0.05) than control group. CONCLUSION: The subject with low HDL-cholesterolemia showed significantly higher AI. Male subject with low HDL-cholesterolemia consumed higher carbohydrate and female subject with low HDL-cholesterolemia showed lower intakes of many nutrients. This result suggests the importance of an adequate and balanced diet to manage type 2 DM patients to prevent CVD complications.
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Citations
Citations to this article as recorded by - Improvement of High-fat Diet-induced Obesity by Xanthigen in C57BL/6N Mice
Kyeong-Mi Choi, Youn-Sun Lee, Wonkyun Kim, Yung-Hyun Choi, Youn-Gil Kwak, Jae-Chul Jung, Jeongrai Lee, Hwan-Soo Yoo
Journal of Life Science.2012; 22(12): 1697. CrossRef - The Prevalence, Awareness and Treatment of High Low Density Lipoprotein-Cholesterol in Korean Adults Without Coronary Heart Diseases - The Third Korea National Health and Nutrition Examination Survey, 2005 -
Sun-Ja Choi, Sung-Hee Park, Kwang-Soo Lee, Hyun-Young Park
Korean Circulation Journal.2012; 42(2): 86. CrossRef - Administration of Triticum aestivum Sprout Water Extracts Reduce the Level of Blood Glucose and Cholesterol in Leptin Deficient ob/ob Mice
Sun-Hee Lee, Sung-Won Lim, Nguyen Van Mihn, Jung-Mu Hur, Bong-Joon Song, Young-Mi Lee, Hoi-Seon Lee, Dae-Ki Kim
Journal of the Korean Society of Food Science and Nutrition.2011; 40(3): 401. CrossRef - Effects of Namhae Specialized Crops Water Extract on Lipid Metabolism in Rats Fed a Cholesterol Diet
Jung-Hye Shin, Min-Jung Kang, Seung-Mi Yang, Soo-Jung Lee, Nak-Ju Sung
Korean journal of food and cookery science.2011; 27(5): 599. CrossRef
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