- Sphenoid Sinus Aspergillosis with Ophthalmoplegia that Occurred in Patients with Diabetes Mellitus.
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Oh Dae Kwon, Jong Yup Bae
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Korean Diabetes J. 2005;29(1):78-82. Published online January 1, 2005
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- Ophthalmoplegia that is caused by spheniod sinus aspergillosis is a rare disease. We report here on two cases of sphenoid sinus aspergillosis with diplopia that occurred in a diabetic patient and an immunocompetent patients. The diabetic patient showed a more rapid progression, severer symptoms and a delayed and incomplete recovery from the neurological deficits. The other patient had milder symptoms, a slower disease course and a more rapid recovery. We suggest that immediate imaging should be performed to diagnose the cause of diplopia in those patients presenting with atypical unilateral persistent facial pain and diplopia, and especially for those patient with diabetes mellitus
- A Differential Effect of Intracellular ATP on Skeletal-and Smooth Muscle-Type KATP Channel Activities.
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Oh Dae Kwon, Jeong Geun Lim, Haeng Gyun Kim, Dae Kwang Kim, Jae Seok Hwang, Keun Gyu Park, Sung Hee Park, Chi Heum Cho, In Kyu Lee, Dae Kyu Song
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Korean Diabetes J. 2003;27(4):332-342. Published online August 1, 2003
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- BACKGROUND
The ATP-sensitive potassium (KATP) channel comprises an inwardly- rectifying K+ channel (Kir) and a sulfonylurea receptor(SUR). This study investigated the mechanism of different ATP sensitivity between skeletal-(Kir6.2/SUR2A) and smooth muscle- (Kir6.2/SUR2B) type KATP channels. METHODS: Messenger RNAs encoding mouse Kir6.2, and rat SUR2A or 2B were co-injected into Xenopus Laevis oocytes to express each type of KATP channel. Using the inside-out patch clamp technique, the channel currents for MgATP sensitivity were measured and analyzed. RESULTS: By addition of 100 microM of MgATP, the current initially decreased and then slowly increased in Kir6.2/SUR2A. This gradual, ATP sensitivity decrease during prolonged MgATP application was totally blocked by LY 294002, a pho- sphatidylinositol-3 and -4 kinase inhibitor. In contrast, a rather rapid sensitivity decrease after initial inhibition was observed in Kir6.2/SUR2B by 100 microM of ATP, which was not blocked by LY 294002. This channel activation was Mg2+- dependent, suggesting that ATP hydrolysis is critical. CONCLUSION: This result supports the idea that the ability of MgATP to stimulate Kir6.2/SUR2B channels reflects a faster rate of ATP hydrolysis at NBD2 of SUR2B.
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KDA
