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Diabetes Metab J : Diabetes & Metabolism Journal


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Kyo Cheol Mun  (Mun KC) 2 Articles
Effect of Melatonin on the Diabetes Mellitus Induced by Streptozotocin in Rats.
Ri Ra Lee, You Hee Kim, Chun Sik Kwak, Mi Young Yeo, Kyo Cheol Mun
Korean Diabetes J. 2002;26(5):357-365.   Published online October 1, 2002
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AbstractAbstract PDF
Oxygen free radicals are related to the pathogenesis and development of diabetes mellitus. The effect of melatonin, a known powerful antioxidant, was studied diabetes mellitus induced by streptozotocin in male Sprague-Dawley rats. METHODS: Diabetes was induced by the intraperitoneal injection of streptozotocin at 65 mg per kg of body weight. To know the effects of melatonin, two doses of 10 mg of melatonin per kg of body weight were administered intraperitoneally, the first simultaneously with the streptozotocin, and the second after a further 72 hours. The rats were then sacrificed at the 7th day after the first injection. The parameters including the levels of blood glucose, hemoglobin A1C, malondialdehyde and antioxidant enzymes were analysed to evaluate the diabetic state and the degree of lipid peroxidation by oxygen free radicals. RESULTS: The injection of streptozotocin caused significant increases in the levels of blood glucose, hemoglobin A1C and malondialdehyde. The injection of melatonin significantly reduced the levels of blood glucose and malondialdehyde. CONCLUSION: These results suggest melatonin may have a protective effect on the oxidative damage in the diabetes induced by streptozotocin.
The Effect of alpha-lipoic Acid on Endothelial Dysfunction Induced by Intralipid Infusion in Healthy Volunteers.
Dong Wook Lee, Mi Jung Kim, Hye Soon Kim, Tae Sung Yun, Ho Chan Cho, Sang Jun Lee, Seung Ho Hur, Kyo Cheol Mun, Yong Won Cho, Jae Hoon Bae, In Kyu Lee
Korean Diabetes J. 2002;26(5):336-346.   Published online October 1, 2002
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AbstractAbstract PDF
Endothelial dysfunciton has been proposed as an early manifestation of atherogenesis. Recently, emerging evidence suggests that hypertriglyceridemia and elevated free fatty acid are important risk factors in the development of atherosclerosis, probably through an increased oxidative stress. To clarify the hypothesis, we evaluated the effect of alpha-lipoic acid (ALA) on the endothelial dysfunction induced by intralipid infusion in healthy volunteers. METHODS: Hypertriglyceridemia and elevated free fatty acids was induced by infusion of intralipid. FMD (Flow-mediated dilation) of the brachial artery was investigated noninvasively by a high-resolution ultrasound technique in 13 young, healthy men without risk factors for coronary heart disease. RESULTS: Plasma triglyceride, free fatty acid and the superoxide anion were increased from 61.7+/-28.8 to 332.6+/-202.5 mg/dL, from 330.7+/-131.1 to 1267.0+/-486.2 microEq/L and from 6.6+/-2.2 to 8.7+/-1.5 X 10(-7)nmol/10(6)cells/30min (vs. basal p<0.001), respectively, following infusion of the intralipid. The FMD was decreased from 10.1+/-3.3 to 7.7+/-3.7% (vs. basal p<0.01) following infusion of the intralipid. After treatment with ALA, the increase in the FMD and the decrease in superoxide anion were significant. CONCLUSION: Acute hypertriglyceridemia, induced by intralipid infusion, is implicated in endothelial dysfunction. This endothelial dysfunction was reversed by treatment with ALA. These results suggest that chronic and repeated hypertriglyceridemia may play important roles in the development of atherosclerosis probably by increasing oxidative stress.

Diabetes Metab J : Diabetes & Metabolism Journal
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