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Jong Park  (Park J) 1 Article
Association of Hemoglobin A1c with Cardiovascular Disease Risk Factors and Metabolic Syndrome in Nondiabetic Adults.
Jin Hwa Kim, So Ra Choi, Jae Rok Lee, Ji Hye Shin, Sang Jun Lee, Mi Ah Han, Jong Park, Hak Yeon Bae, Sang Yong Kim
Korean Diabetes J. 2008;32(5):435-444.   Published online October 1, 2008
DOI: https://doi.org/10.4093/kdj.2008.32.5.435
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  • 6 Citations
AbstractAbstract PDF
BACKGROUND
Glycosylated hemoglobin (HbA1c) is a useful index of mean blood glucose concentrations over the preceding 2 to 3 months. Elevated HbA1c levels (> 7%) are associated with a higher incidence of microvascular and macrovascular complications in patients with diabetes mellitus. However, the relationship between HbA1c and cardiovascualr disease risk in nondiabetic adults has been unclear. The aim of this study is to estimate the association of HbA1c with cardiovascular disease risk factors and metabolic syndrome in nondiabetic adults. METHODS: The subjects of this study included 533 adults (180 males and 353 females) aged 20~70 years (mean age: 46.9 +/- 10.12 years) without previously diagnosed diabetes who lived in Kangyang country. We examined baseline HbA1c levels and cardiovascular risk factors. Metabolic syndrome was defined based on International Diabetes Federation guidelines. RESULTS: The prevalence of metabolic syndrome significantly increased as HbA1c increased. HbA1c revealed a significant correlation with age (r = 0.258, P < 0.001), BMI (r = 0.152, P < 0.001), waist circumference (r = 0.252, P < 0.001), fasting plasma glucose (r = 0.319, P < 0.001), systolic (r = 0.100, P = 0.021), diastolic (r = 0.115, P = 0.008) blood pressure, total cholesterol (r = 0.232, P < 0.001), triglyceride (r = 0.156, P < 0.001), LDL cholesterol (r = 0.216, P < 0.001), and HDL cholesterol (r = -0.167, P < 0.001). Multiple regression analysis showed that HbA1c had a association with age, fasting plasma glucose, and dyslipidemia. The receiver operating characterstics (ROC) curve analysis determined HbA1c of 5.35% to yield optimal sensitivity and specificity corresponding to the presence of metabolic syndrome. CONCLUSION: The HbA1c level is correlated with cardiovascular risk factors and prevalence of metabolic syndrome in nondiabetic adults.

Citations

Citations to this article as recorded by  
  • Association of Glycated Proteins with Inflammatory Proteins and Periodontal Disease Parameters
    Jeneen Panezai, Mohammad Altamash, Per-Erik Engstrӧm, Anders Larsson
    Journal of Diabetes Research.2020; 2020: 1.     CrossRef
  • The Impact of Health Behaviors of Male Workers without Diabetes on HbA1c
    Ji-Yun Park, Keon-Yeop Kim, Su-Jin Lee
    Journal of Health Informatics and Statistics.2018; 43(4): 344.     CrossRef
  • Impact of initial glycosylated hemoglobin level on cardiovascular outcomes in prediabetic patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention
    Donghun Shin, Jinhee Ahn, Kwang Soo Cha, Jin Sup Park, Jun-Hyok Oh, Hye-Won Lee, Ju-Yong Hong, Bo-Won Kim, Taek Jong Hong
    Coronary Artery Disease.2016; 27(1): 40.     CrossRef
  • HbA1c Levels Are Associated with Chronic Kidney Disease in a Non-Diabetic Adult Population: A Nationwide Survey (KNHANES 2011–2013)
    Seok Hui Kang, Da Jung Jung, Eun Woo Choi, Kyu Hyang Cho, Jong Won Park, Jun Young Do, Sheng-Nan Lu
    PLOS ONE.2015; 10(12): e0145827.     CrossRef
  • Usefulness of Glycated Hemoglobin as Diagnostic Criteria for Metabolic Syndrome
    Sang Hyun Park, Ji Sung Yoon, Kyu Chang Won, Hyoung Woo Lee
    Journal of Korean Medical Science.2012; 27(9): 1057.     CrossRef
  • Relationship between inflammation biomarkers, antioxidant vitamins, and bone mineral density in patients with metabolic syndrome
    Yesong Lee, Misung Kim, Kyungsuk Choi, Juyong Kim, Wookyung Bae, Sohye Kim, Cheongmin Sohn
    Nutrition Research and Practice.2011; 5(2): 150.     CrossRef

Diabetes Metab J : Diabetes & Metabolism Journal