- Effects of Nateglinide on the Control of Mealtime Glucose Excursions in Korean Patients with Type 2 Diabetes.
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Hyeon Man Kim, Yoon Seok Chung, Kwan Woo Lee, Dae Jung Kim, Hyun Chul Lee, Dong Rim Kim, Dong Seop Choi, Eun Sook Oh, Moo Il Kang, Kwang Woo Lee, Chul Young Park, In Myung Yang, Jin Woo Kim, Young Seol Kim, Hyong Gi Jung
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Korean Diabetes J. 2002;26(5):405-415. Published online October 1, 2002
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- BACKGROUND
Nateglinide belong to a new family of insulin secretagogues that stimulate the early phase of insulin secretion. This study was designed to evaluate the efficacy and adverse effect of nateglinide in Korean type 2 diabetes patients, whose diabetes were inadequately controlled by medical nutrition therapy, focusing on the changes in mealtime glucose excursion (PBG), fasting blood glucose (FBG), glycated hemoglobin (HbA1c) and plasma insulin. SUBJECTS AND METHODS: This multicentered open-label trial was conducted on 66 Korean patients with type 2 diabetes mellitus. The subjects comprised of 36 males and 30 females, with a mean age, and duration of diabetes of 53.9+/-9.6(34~69) years and 39.5+/-44.0 months, respectively. The inclusion criteria were as follows: 1) FBG and PBG before the trial of 6.7~11.1 mmol/l and above 11.1 mmol/l, respectively, 2) changes of FBG and PBG during the 2-week-diet treatment of less than 1.7 mmol/l. PBG, FGB, HbA1c and plasma insulin levels were measured at weeks -2, 0, 2, 4, 8 and 12. Any adverse effects were noted during the study. The data were analyzed by the intent-to treat (ITT) and the per protocol (PP) methods. RESULTS: Nineteen cases were excluded due to protocol violation or withdrawal. The PBG level was significantly decreased during the study 13.7 2.6 mmol/l, before the trail to 9.6 2.8 mmol/l after (p=0.001) which was particularly marked during the first 2 weeks. The FBG, HbA1c and fasting plasma insulin levels were also significantly decreased, from 9.0+/-1.2 to 8.2+/-2.0 mmol/l, p=0.0063), from 8.0+/-1.3% to 7.0+/-1.1% (p=0.0001) and from 9.8 7.2 to 8.0 5.5 pmol/l (p<0.05), respectively. Three adverse events suggested the nateglinide-related diabetes was not serious. CONCLUSION: This study revealed that nateglinide could be used as an effective glucose-lowering agent, especially for the control of mealtime glucose excursion in Korean type 2 diabetes patients who were inadequately controlled by diet alone.
- Gastric Dysfunction Assessed by Electrogastrography and the Acetaminophen Absorption Technique in Patients with Diabetic Neuropathy.
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Hyun Ha Chang, Young Seol Kim, Sang Hwa Kim, Cheol Young Park, Seung Joon Oh, Jeong Taek Woo, In Myung Yang, Sung Woon Kim, Jin Woo Kim, Young Kil Choi
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Korean Diabetes J. 2001;25(1):83-92. Published online February 1, 2001
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- BACKGROUND
In patients with diabetes mellitus, dysrhythmias of gastric myoelectrical activity are frequently associated with gastroparesis. Thus, we investigated the relationships between abnormal gastric myoelectrical activity and gastric emptying rate in patients with diabetes mellitus. METHODS: Using surface electrogastrography (Nippro, Tokyo, Japan) and acetaminophen absorption technique, we studied EGG and gastric emptying rate in 39 patients with diabetic neuropathy and 15 healthy volunteers as the control group. RESULTS: In two thirds of the patients with diabetes mellitus, fasting electrogastrography revealed instability of electrical control activity (ECA), as compared to 13% of the control. Postprandial amplitude and frequency increases in electrogastrography were observed in the control group. However, these postprandial responses were obtunded in patients with diabetes mellitus. In the assessment of gastric emptying rate, increases of plasma acetaminophen levels were delayed in obtunded postprandial responses of gastric myoelectrical activity. CONCLUSION: These results showed that the abnormal electrogastrography patterns were related to abnormal finding assessed acetaminophen absorption technique. Electrogastrography was thought to be a useful and non-invasive technique in assessing diabetic gastroparesis.
- Free Testosterone and Sex Hormone-Binding Globulin Level in Type 2 Diabetic Men.
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Ki Deuk Nam, Young Seol Kim, Cheol Young Park, Seung Joon Oh, Deog Yoon Kim, Jeong Taek Woo, Sung Woon Kim, In Myung Yang, Jin Woo Kim, Young Kil Choi
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Korean Diabetes J. 2000;24(6):699-707. Published online January 1, 2001
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Insulin resistance is a risk factor for cardiovascular disease and type 2 diabetes mellitus. There are many previous studies indicating that insulin lowers serum sex hormone-binding globulin levels, and there is inverse correlation between insulin resistance and serum sex hormone-binding globulin levels in women. However, in men, a limited number of studies are available to explain the effect of sex hormone on age and insulin. Therefore, the present study was undertaken to investigate the relationship among free testosterone, hormone- binding globulin and age in type 2 diabetic men and control subjects. METHOD: Age, body mass index, total cholesterol, triglyceride, fasting blood sugar, and insulin concentrations were examined on 89 type 2 diabetic men and 47 control subjects. The free testosterone level was measured by commercially available double-antibody system (Radioimmunoassay). The sex hormone-binding globulin level was also measured by commercially available double-antibody system(Immunoradiometric assay). RESULTS: 1) Sex hormone-binding globulin level was significantly increased in patients with type 2 diabetes. However, there was no significant difference in free testosterone level between the two groups. 2) Sex hormone-binding globulin was positively correlated with age (r=0.4, p<0.001) in patients with type 2 diabetes. Sex hormone-binding globulin and free testos terone were not correlated with age in control sujects. 3) Free testosterone and sex hormone-binding globulin concentrations were not significantly related to serum insulin concentration after adjusting for age and body mass index. CONCLUSIONS: We observed increased sex hormone-binding globulin concentration in diabetes man, and was a positively related to age. Further studies are needed to understand the relationships between age, insulin resistance, testosterone, and sex hormone-binding globulin concentrations.
- Lowering Effect of Voglibose, Monotherapy on Uncontrolled Postprandial Glucose in Patients with Non-Insulin Dependent Diabetes Mellitus (NIDDM) Being Treated with Strict Diet Control: Multicenter Open-Study.
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Jeong Taek Woo, Young Seol Kim, Young Kil Choi, Jin Woo Kim, In Myung Yang, Sung Woon Kim, Deog Yoon Kim, Kwang Won Kim, Moon Kyu Lee, Myung Shik Lee, Jae Hoon Jung, Kyu Jeong Ahn, Hyun Chul Lee, Young Deuk Song, Bong Soo Cha, Jee Hyun Lee, Hyung Joon Won
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Korean Diabetes J. 1998;22(3):419-428. Published online January 1, 2001
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It is sometimes very difficult to control the elevation of postprandial glucose with diet therapy only in patients with NIDDM partly because of their defective insulin response to glucose. Recently the alpha-glucosidase inhibitors which inhibit carbohydrate digestion and suppress or delay absorption of the final breakdown products, glucose and fructose when it is taken orally with meal have been widely used in the treatment of diabetes. The drugs, however, provoke the adverse effects e.g. flatulence, diarrhea etc. in some patients. Therefore we studied the efficacy of the more recently developed alpha glucosidase inhibitor, Voglibose (Basen, Cheiljedang) METHODS: Fifty five patients whose postprandial two hour serum glucose levels were more than 11.1 mmol/L despite the strict diet therapy during the 4 week observation period were assigned to receive Voglibose 0.2 mg before each meal t.i.d. for 8 weeks. Of 55 subjects, 41 were given Voglibose 0.3 mg t..i.d. for the last 4 weeks because of their poor glucose control, RESULTS: The postprandial one and two hour serum glucose levels significantly decreased after therapy; 1 hour: 17.5+4.4 mmol/L(prior to therapy), 15.4+3.8 mmol/L(4 week after), 14.8+5.1 mmol/L(8 week), p <0.00l, 2 hour: 16.7+4.5 mmol/L, 14.8+3.9 mmol/ L, 14.8+4.5 mmol/L, p<0.00 l, t-tests for paired samples. Total serum cholesterol and HDL cholesterol levels also significantly decreased(5.24+1.06 - 4.90+1.27 mmol/L, p=0.036, 1.34+0.66 1.16 +0.3l mmol/L, p=0.035 respectively) However, HbAlc, serum fructosamine, insulin and triglyceride levels were not significantly changed. The prevalence of the adverse effects due to Voglibose was 14%(10/71). All of them were less than grade II of WHO criteria and disappeared despite continuing therapy. CONCLUSION: Voglibose monotherapy is considered as having an glucose lowering effect in patients with NIDDM whose adequate postprandial blood glucose cannot be achieved with diet therapy only.
- Clinical effect of topical capsaicin in painful diabetic polyneuropathy.
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Dai Ok Cho, Jae Man Kim, Deog Yoon Kim, Jeong Taek Woo, Sung Woon Kim, In Myung Yang, Jin Woo Kim, Young Seol Kim, Kwang Won Kim, Young Kil Choi
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Korean Diabetes J. 1993;17(4):411-417. Published online January 1, 2001
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- A clinical study on the diabetic foot lesions.
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Jae Man Kim, Deog Yoon Kim, Jeong Taek Woo, Sung Woon Kim, In Myung Yang, Jin Woo Kim, Young Seol Kim, Kang Won Kim, Young Kil Coi
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Korean Diabetes J. 1993;17(4):387-394. Published online January 1, 2001
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- The influence of feedback inhibition of insulin secretion by insulin itself in isolated rat islets.
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Sung Hoon Kim, Sung Yi Kang, Deog Yoon Kim, Kwang Sik Seo, Jeong Taek Woo, Sung Woon Kim, In Myung Yang, jin Woo Kim, Young Seol Kim, Kwang Won Kim, Young Kil Choi
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Korean Diabetes J. 1993;17(1):35-43. Published online January 1, 2001
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- Three dimensional long-term culture of rat islets using gelatin gel.
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Deog Yoon Kim, Kwang Sik Seo, Eun Mi Koh, Jeong Taek Woo, Seong Woon Kim, In Myung Yang, Jin Woo Kim, Young Seol Kim, Kwang Won Kim, Young Kil Choi
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Korean Diabetes J. 1992;16(4):299-307. Published online January 1, 2001
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- Serum lipoprotein(a) concentration in patients with diabetic retinopathy.
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Seung Joon Oh, Deog Yoon Kim, Jung Taek Woo, Sung Woon Kim, In Myung Yang, Ji Woo Kim, Young Seol Kim, Kwang Won Kim, Young Kil Choi
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Korean Diabetes J. 1992;16(4):281-287. Published online January 1, 2001
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- Combined effect of hyperglycemia and interleukin-1 beta on the insulin secretion of isolated rat islets.
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Kwang Won Kim, Deog Yoon Kim, Kwang Sik Seo, Eun Mi Koh, Jeong Taek Woo, Sung Woon Kim, In Myung Yang, Jin Woo Kim, Young Seol Kim, Young Kil Choi
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Korean Diabetes J. 1992;16(3):187-198. Published online January 1, 2001
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