- Increased Plasma Dipeptidyl Peptidase IV Activities in ob/ob Mice.
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Sang Dal Rhee, Young Sil Lee, Hye Sung Lee, Won Hoon Jung, Hyae Gyeong Cheon, Jin Hee Ahn, Sung Su Kim, Sang Gi Paik, Sung Don Yang
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Korean Diabetes J. 2005;29(1):22-29. Published online January 1, 2005
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 Abstract
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Dipeptidyl peptidase IV (DPP IV/CD26), a multi-functional glycoprotein, cleaves and inactivates major insulinotropic hormones, such as glucagon-like protein (GLP)-1 and glucose dependent insulinotrophic polypeptide (GIP). METHODS: The plasma DPP IV activities in ob/ob mice were measured at 4, 8 and 13 weeks of age and the correlation between the plasma glucose concentration and DPP IV activity analyzed at 7~9 weeks of age. The glucose lowering effects of P32/98, a DPP IV inhibitor, was assessed with the oral glucose tolerance test. RESULTS: The plasma DPP IV activities in ob/ob mice were higher than those in lean mice. The plasma DPP IV activity was correlated with the plasma glucose concentration both in male and female ob/ob mice. The glucose lowering effect of DPP IV inhibitor was more prominent in ob/ob than in lean mice. CONCLUSION: The plasma DPP IV activities in ob/ob mice were higher than in lean control mice, which may contribute to the higher glucose lowering effect of the DPP IV inhibitor in ob/ob mice
- Characteristics of the Newly Established Diabetic Model Mice, TallyHo.
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Sang Dal Rhee, Won Hun Jeong, Yoon Young Sung, Hye Sung Lee, Kun Bock Lee, Hee Yeon Kim, Sung Don Yang
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Korean Diabetes J. 2004;28(3):177-186. Published online June 1, 2004
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Abstract
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TallyHo(TH) mice are a newly established model for non-insulin dependent diabetes mellitus(NIDDM), for polygenic causative genes that have not yet been identified. It has been reported that TH mice show mild obesity, hyperinsulinemia, hyperlipidemia and male-limited hyperglycemia. The characteristics of these mice were examined. METHODS: Diabetes related physiological data of TH mice, such as body weight, the plasma concentration of biochemical parameters(glucose, triglyceride and nonesterified free fatty acid) and changes in the pattern of the oral glucose tolerance test(OGTT), were obtained up to the age of 35 weeks. The insulin tolerance test(ITT) was performed at 7 weeks of age and the weights of the fat pad and liver were measured at 35 weeks of age. RESULTS: TH mice revealed hyperlipidemia, glucose intolerance and disturbed insulin tolerance, even when prediabetic at 7 weeks of age. Hyperglycemia and hyper- insuline-mia were observed as early as 10 weeks of age; however, individual variations in the blood glucose level were large at this age. Obesity in TH mice seems to be caused by the predominant deposition of visceral fat. CONCLUSION: These results suggest that TH mice are an appropriate rodent model for diabetes with visceral obesity and insulin resistance.
- Effects of Smoking on Plasma Lipid Metabolism in Patients with non-insulin Dependent Diabetes Mellitus.
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Seon Min Jeon, Yeun Kyung Lee, Hye Sung Lee, Bo Wan Kim, Young Bok Park, Myung Sook Choi
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Korean Diabetes J. 1997;21(4):457-468. Published online January 1, 2001
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Abstract
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Diabetes mellitus has been identified as a risk factor in the development of coronary vascular disease. Smoking also has been known as an independent risk factor in the development of coronary artery disease, causing a dislipidemia. This study was carried out to examine the effects of smoking on plasma lipids and lipoproteins metabolism in patients with NIDDM and in normal healthy subjects among Korean population in Taegu. METHODS: The 80 patients with NIDDM and 60 normal subjects were suMivided into non-stnoker, ex-smoker, and smoker group. Antbropornetric assessments, mean intake of nutrients, and the levels of plasma lipids, Apo A-I, L,p(a), CETP activity, and antioxidant vitamins such as vitamin A, E were measured, RESULTS: WHR in non-smoker of patients with NIDDM was greater than that in non-smoker of normal control. There were no differences in the nutrient intakes among groups, but protein intake was even higher in smoker of NIDDM group than that of normal group. There were no smoking effect on total cholesterol, LDL-C, AI, Apo A-I, Lp(a) and lipid peroxide in plasma of two groups, but they were higher in NIDDM group than normal group. Plasma TG concentrations were higher in smoker group than other groups within normal group, HDL-C levels were lower in non-smoker group than other groups within NIDDM group. CETP activities were higher in smoker group than non-smoker within normal group. And CEPT activities in NIDDM group were mostly higher than those of normal group. Vit. A levels of non-smoker in normal group were higher than ex-smoker within same group, and were also higher than non-smoker in NIDDM group. Vit. E levels showed no difference within each group, but they were mostly lower in NIDDM group than normal group. CONCLUSION: It was concluded that smoking was not a major factor for changing lipid metabolism in NIDDM patients as well as normal subjects unlike others findings. Their abnormal lipid rnetabolism may be induced from other risk factors for NIDDM rather than smoking itself. However, present study was done only for a short period, thus more studies are needed for longer term to investigate the effects af smoking on lipid metabolism in NIDDM among Korean population.
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