- Mutations in Hepatocyte Nuclear Factor-la in Early-Onset Type 2 Diabetes Mellitus in Korea.
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Kyoung Ah Kim, Myung Shik Lee, Kyu Jeung Ahn, Jae Hoon Chung, Yong Ki Min, Moon Kyu Lee, Ki Up Lee, Ghi Su Kim, Kyoung Ho Suk, Dae Yeun Hwang, Kwang Won Kim
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Korean Diabetes J. 1999;23(6):793-802. Published online January 1, 2001
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 Abstract
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- BACKGROUND
Type 2 diabetes mellitus is a heterogeneous disorder caused by the unfavorable combination of genetic and environmental factors. Maturity-onset diabetes of the young (MODY) is a rare form of familial type 2 diabetes mellitus characterized by an early onset, and it is appearance in at least three consecutive generations, consistent with an autosomal dominant mode of inheritance. It accounts for 1~3% of type 2 diabetes mellitus cases. As of today, five different MODY genes have been identified. In 1996, Yamagata et al. reported that MODY3 and MODY 1 were caused by mutations in hepatocyte nuclear factor (HNF) la and 4a, respectively. Furthermore, there have been reports that HNF-la gene mutation could be a cause of early-onset type 2 diabetes mellitus with familial history, although these patients do not fulfill the clinical criteria of MODY. Therefore, the purpose of this study was to examine the mutation of HNF-la gene in early-onset type 2 diabetes mellitus in Korean subjects. METHODS: Sixteen cases of early-onset type 2 diabetes mellitus with familial history were included in the study. Five of these subjects were MODY patients according to our revised criteria. DNA was isolated from peripheral blood. The 10 exons and flanking introns of the HNF-1 a gene were amplified by polymerase chain reaction (PCR). The PCR products were sequenced using an AmpliTaq FS Dye Terminator Cycle Sequencing Kit (Perkin-Elmer Applied Biosystems). RESULT: Mutation in the HNF-la gene was identified in 1 of the 16 patients. It was a hitherto unreported novel missense mutation, R263L. This mutation co-segregated with type 2 diabetes mellitus or impaired glucose tolerance in his family and was not found in family members with normal glucose tolerance. CONCLUSION: Findings from this study suggests that MODY3 caused by mutation of HNF-la gene is also present in early onset type 2 diabetic of Korean subjects. This is the first time that HNF-la mutation causing MODY was identified in Korea.
- The prevalence of micro-and macrovascular complications of korean niddm patients.
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Joong Yeol Park, Sang Wook Kim, Goo Yeong Cho, Mee Hwa Lee, Soo Jung Je, Ki Up Lee, Ghi Su Kim
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Korean Diabetes J. 1993;17(4):377-385. Published online January 1, 2001
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- No abstract available.
- Follow-up of glomerular hyperfiltration in non-insulin-dependent diabetes mellitus.
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Il Ran Hwang, Ki Up Lee, Joong Yeol Park, Dae Hyuk Moon, Ghi Su Kim
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Korean Diabetes J. 1993;17(2):169-174. Published online January 1, 2001
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- No abstract available.
- Effect of acipimox(olbetam)treatment on plasma lipids and glucose in hyperlipidemic patients with type 2 diabetes mellitus.
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Ki Up Lee, Soojung Je, Joong Yeol Park, Ghi Su Kim, Mun Ho Lee
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Korean Diabetes J. 1993;17(1):105-110. Published online January 1, 2001
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- No abstract available.
- The prevalence of various complications in relation to age and duration of diabetes mellitus.
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Jin Sook Ryu, Ki Up Lee, Yong Tae Kim, Young Kee Shong, Ghi Su Kim, Munho Lee
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Korean Diabetes J. 1992;16(2):145-150. Published online January 1, 2001
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- No abstract available.
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