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Eun Gyoung Hong  (Hong EG) 9 Articles
Letter: The Current Status of Type 2 Diabetes Management at a University Hospital (Korean Diabetes J 33(3):241-250, 2009).
Eun Gyoung Hong
Korean Diabetes J. 2009;33(4):353-354.   Published online August 1, 2009
DOI: https://doi.org/10.4093/kdj.2009.33.4.353
  • 1,738 View
  • 16 Download
AbstractAbstract PDF
No abstract available.
Responses: Risk Factors for Early Development of Macrovascular Complications in Korean Type 2 Diabetes (Korean Diabetes J 33(2):134-142, 2009).
Hae Ri Lee, Eun Gyoung Hong
Korean Diabetes J. 2009;33(3):259-260.   Published online June 1, 2009
DOI: https://doi.org/10.4093/kdj.2009.33.3.259
  • 1,944 View
  • 16 Download
AbstractAbstract PDF
No abstract available.
Risk Factors for Early Development of Macrovascular Complications in Korean Type 2 Diabetes.
Hae Ri Lee, Jae Myung Yu, Moon Gi Choi, Hyung Joon Yoo, Eun Gyoung Hong
Korean Diabetes J. 2009;33(2):134-142.   Published online April 1, 2009
DOI: https://doi.org/10.4093/kdj.2009.33.2.134
  • 2,321 View
  • 27 Download
  • 4 Crossref
AbstractAbstract PDF
BACKGROUND
The average duration of diabetes and predictive factors of macrovascular complications in Korean diabetic patients remain to be elucidated. This study examines the average duration of diabetes up to the onset of macrovascular complications and clinically important factors of early development of these complications in Korean type 2 diabetic patients. METHODS: Clinical characteristics in type 2 diabetics with (n = 121) and without macrovascular complications (n = 115) were analyzed. In addition, early onset (< or = 5 years, n = 54) and late onset groups (> 5 years, n = 67) were compared, as were the clinical characteristics between male and female patients in the macrovascular complications group. RESULTS: The average duration of diabetes was 8.7 +/- 7.8 years in the macrovascular complications group. Average age, systolic and diastolic blood pressures and smoking history were all higher in the macrovascular complications group than the control group. However, HbA1c levels and prevalence of microvascular complications were higher in the controls. Average age was lower in the early onset group and many more patients of that group had a smoking history. In the analysis based on sex, marcrovascular complications developed earlier in male patients. In addition, the prevalence of family history of diabetes was higher in males and 77.8% of male patients had a smoking history (female: 3.4%). CONCLUSION: Our study confirms that older age, high blood pressure and smoking history are major risk factors for the development of macrovascular complications. Moreover, a smoking history in males can be both risk and predictive factors for earlier development of macrovascular complications in Korean type 2 diabetic patients. We also found that several clinical characteristics including age, family history of diabetes, hypertension and smoking history, vary between the sexes, and these findings can provide useful indices for the prevention of macrovascular complications.

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  • Impact of new-onset diabetes on clinical outcomes after ST segment-elevated myocardial infarction
    Ji-Yeoun Seo, Jin-Sun Park, Kyoung-Woo Seo, Hyoung-Mo Yang, Hong-Seok Lim, Byoung-Joo Choi, So-Yeon Choi, Myeong-Ho Yoon, Gyo-Seung Hwang, Seung-Jea Tahk, Joon-Han Shin
    Scandinavian Cardiovascular Journal.2019; 53(6): 379.     CrossRef
  • Associations Between the Continuity of Ambulatory Care of Adult Diabetes Patients in Korea and the Incidence of Macrovascular Complications
    Young-Hoon Gong, Seok-Jun Yoon, Hyeyoung Seo, Dongwoo Kim
    Journal of Preventive Medicine and Public Health.2015; 48(4): 188.     CrossRef
  • Relationship of Daily Activity and Biochemical Variables in the Elderly with Diabetes Mellitus
    Ki-Wol Sung
    Journal of Korean Academy of Nursing.2011; 41(2): 182.     CrossRef
  • Epidemiology of Micro- and Macrovascular Complications of Type 2 Diabetes in Korea
    Jung Hee Kim, Dae Jung Kim, Hak Chul Jang, Sung Hee Choi
    Diabetes & Metabolism Journal.2011; 35(6): 571.     CrossRef
Anti-GAD Antibody in Patients with Adult-Onset Diabetes in Korea.
Eun Gyoung Hong
Korean Diabetes J. 2009;33(1):13-15.   Published online February 1, 2009
DOI: https://doi.org/10.4093/kdj.2009.33.1.13
  • 2,290 View
  • 19 Download
  • 1 Crossref
AbstractAbstract PDF
No abstract available.

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  • Management of Adults with Type 1 Diabetes: Current Status and Suggestions
    Sang-Man Jin, Jae Hyeon Kim
    The Journal of Korean Diabetes.2014; 15(1): 1.     CrossRef
Clinical Significance of Decreased Glomerular Filtration Rate (GFR) without Albuminuria among Type 2 Diabetics (Korean Diabetes Journal 32(3):252-258, 2008).
Eun Gyoung Hong
Korean Diabetes J. 2008;32(4):386-387.   Published online August 1, 2008
DOI: https://doi.org/10.4093/kdj.2008.32.4.386
  • 1,893 View
  • 16 Download
AbstractAbstract PDF
No abstract available.
Diabetic Nephropathy - Preventive effects of lithospermic acid B (LAB).
Eun Gyoung Hong
Korean Diabetes J. 2008;32(1):7-9.   Published online February 1, 2008
DOI: https://doi.org/10.4093/kdj.2008.32.1.7
  • 2,035 View
  • 18 Download
  • 1 Crossref
AbstractAbstract PDF
No abstract available.

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  • Natural Compounds as Source of Aldose Reductase (AR) Inhibitors for the Treatment of Diabetic Complications: A Mini Review
    Ajmer Singh Grewal, Komal Thapa, Neha Kanojia, Neelam Sharma, Sukhbir Singh
    Current Drug Metabolism.2020; 21(14): 1091.     CrossRef
Evaluation of 25% and 50% -75 gm Oral Glucose Tolerance Test - Animal and Clinical Pilot Study: Emphasis on Glucose Kinetics and Preference Evaluation.
Nam Han Cho, Eun Gyoung Hong
Korean Diabetes J. 2000;24(3):385-392.   Published online January 1, 2001
  • 891 View
  • 19 Download
AbstractAbstract PDF
BACKGROUND
Oral glucose tolerance test to diagnose diabetes was first introduced by Jarney and Isaacson in 1918. This method was advocated because of its diagnostic accuracy and also provides the two hours glucose changing pattern. Twenty-five percent (296 mL) glucose solution has been used as the standard diagnostic method in Korea. However, large volume of the solution frequently cause vomiting during the tests. Thus, 50% solution (150 mL) was recently introduced, but the potential difficulty of gastric emptying caused by its hyperosmolarity, and degree of diagnostic accuracy was questioned. Therefore, in this study, we evaluated two type of solutions by comparing the followings in both an animal and human models: (1) glucose changing pattern during the two hour oral glucose tolerance test, (2) Preference evaluation in human model. METHODS: Fifteen male Sprague-Dawley rats and 15 human subjects underwent 2 hours OGTT after 10~14 hours fasting. Two grams glucose per kg body weight was feed to the SD rat. In human, 75 gm glucose in 296 mL (25%) and 150 mL (50%) glucose solution was ingested at two different time, but testing was done within 24 hours a part. Five blood samples (fasting, 30, 60, 90, and 120 minutes) were collected and separated for serum. Glucose was assayed using YSI 2300-STAT (Yellow Springs Instrument Co., Ohio, USA) by glucose oxidase method. RESULTS: In animal study, despite the lower fasting glucose level, 30, 60 and 120 minutes glucose level was higher in 50% solution when compared to the 25% but the mean values were not statistically different. The glucose area under the curve (GAUC) in 50% was higher than 25% but not statistically different. The peak glucose level was observed at 60 minutes in both solutions. In human study, although mean values were not statistically different, all glucose values except 30 minutes were higher in 50% solution. Furthermore, GAUC was not statistically different between the two solutions. In preference test, the study subjects significantly (p<0.05) preferred the 50% solution as more favorable amount for the test. No differences in the tolerable level of sweetness, level of thirsty after ingestion, nausea, vomiting, head and stomachache was observed. CONCLUSION: In this study, we found that the gastro-intestinal glucose kinetics of the 25% and 50% glucose solution used during the OGTT was very similar in both an animal and human model. Furthermore, the preference evaluation showed favorable results in 50% solution. The use of 50% solution reconcile vomiting problem during the test but the same diagnostic accuracy was preserved. Therefore, 50% solution merits its scientific value as the diagnostic solution, and hope to contribute to favor the OGTT for diagnosis of diabetes mellitus in the future.
Microvascular Complications and lts Relationship with Obesity in Outpatient Type 2 Diabetics.
Seong Kyu Lee, Bong Nam Chae, Eun Gyoung Hong, Hye Lim Noh, Hyeon Kyoung Cho, Yoon Jung Kim, Mi Deok Lee, Yoon Sok Chung, Kwan Woo Lee, Nam Han Cho, Hyeon Man Kim
Korean Diabetes J. 2000;24(1):60-70.   Published online January 1, 2001
  • 1,161 View
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AbstractAbstract PDF
BACKGROUND
Korean type 2 diabetic patients who are frequently non-obese, may be genetically different from Western type 2 diabetics who are frequently obese. Therefore, the diabetic complications of type 2 diabetes mellitus in Korea may be also different from those of Western countries. Until now, most studies reported in Korea did not analyse the microvascular complications of type 2 diabetes mellitus according to obesity, and also the criteria in the diagnosis of microvascular complications were different in each study. We investigated the microvascular complications and its relationship with obesity, in type 2 diabetic patients visiting an outpatient clinic. METHODS: The study subjects were type 2 diabetic patients visiting an outpatient clinic of Ajou University Hospital. We selected patients participating in a 75 g oral glucose tolerance test, retrospectively. Type 2 diabetes was diagnosed according to the WHO/NDDG classification of diabetes. Biochemical studies including lipid profile, plasma insulin and C-peptide levels were done. Anthropometric measurements were performed. Based on BMI (kg/m2), the patients were divided into the following groups: the lean group, whan the BMI was less than 20kg/m2; the ideal body weight (IBW) group, if the BMI was between 20 kg/m and 25 kg/m in women and 20kg/m and 27 kg/m in men; and the obese group, when the BMI was>25 kg/m in women and >27 kg/m2 in men. RESULTS: 1. Neuropathy (45.2%) was the most frequent among the microvascular complications, and the frequency of retinopathy was 15.1%, and that of nephropathy was 4.9k. Within 5 years of diabetes duration, the frequency of neuropathy, retinopathy, and nephropathy was 43.2%, 11.8%, and 2,9%, respectively. 2. Glycosylated hemoglobin (HbA1c) and fasting blood glucose levels were not different among the three groups. Beta cell function{delta(insulin 30min insulin Omin)/delta(glucose 30min - glucose Omin)} was the highest in the obese group, However, beta cell function(delta/delta G) divided by the basal insulin level, considered insulin resistance, was not different among the three groups. 3. Within 5 years of diabetes duration, retinopathy tended to be the most frequent in the lean group, whereas neuropathy tended to be the most frequent in the obese group, and body mass index influenced the retinopathy and neuropathy, statistically significantly. CONCLUSION: Diabetic neuropathy was the most frequent among microvascular complications of type 2 diabetes mellitus in our study subjects. At the time of presentation within 5 years of diabetes duration, the lean group of type 2 diabetics had a tendency of the more frequent retinopathy, the obese group had a tendency of the more frequent neuropathy. These results suggest that type 2 diabetes mellitus in Korea is also not a singie disease entity, as in Western countries and is a heterogenous group of disorders with a diversity of microvascular complications. However, the more studies about this will be required.
The Role of Insulin Secretion and Insulin Resistance in the Development of Korean Type 2 Diabetes Mellitus.
Bong Nam Chae, Seong Kyu Lee, Eun Gyoung Hong, Yoon Sok Chung, Kwan Woo Lee, Hyeon Man Kim
Korean Diabetes J. 1998;22(4):491-503.   Published online January 1, 2001
  • 1,129 View
  • 17 Download
AbstractAbstract PDF
BACKGROUND
Impaired insulin secretinn, peripheral insulin resistance, a disproportionately elevated rate of hepatic glucose production and influence of inherited or enviromental factors contribute to the pathogenesis of type 2 diabetes mellitus(DM). But, which defect is primary is still controversial To determine whether insulin resistance or insulin deficiency is primary in the pathogenesis of type 2 DM, we studied normal glucose tolerant offsprings of type 2 diabetic patients. METHODS: 22 offsprings of type 2 diabetic patients with normal glucose tolerance, ranging in age from 20 to 40 years, and 17 control subjects in same age range who had no family history of diabetes, and 21 diabetic subjects were included. We performed 75 g oral glucose tolerance test, euglycemic hyper-insulinemic clamp test and hyperglycemic clamp test. RESULTS: With euglycemic clamp test, the values of peripheral insulin sensitivity, M, were 8.59+0.94 mg/kg/min in control group, 6.98+0.65 mg/kg/min in offspring group, and 5.19+0.89 mg/kg/min in diabetes group (P<0.05). Considering that lower limit of the normal range were 3.78 mg/kg/min in M and 3.10 mg/kg/min in M/I, the frequency of insulin resistance was 14.3% in the offspring group and 33.3 % in diabetes group. First and second phase insulin secretion during hyperglycemic clamp test were blunted in diabetes group. In the offspring group, first and second phase insulin secretion during hyperglycemic clamp test were increased greater than control group, though statistically insignificant. The mean first phase insulin secretion were 38.55+6.81 pU/mL in control group, 55.09+9.40 pU/mL in the offspring group and 6.02+0.98 pU/mL in diabetes group (P<0.05). The mean second phase insulin secretion were 65.11+15.5 pU/mL in control group, 90.25 + 11.9 pU/mL in the offspring group and 17.6 +2.71 pUmL in diabetes group(P<0,05). Considering that lower limit of the normal range were 19.5 pU/mL in the first phase insulin secretion and 26.1 pU/mL in the second phase insulin secretion, the frequency of impaired insulin secretion was 14.3 % in the offspring group and 100 % in diabetes group. There was an inverse relation between insulin resistance and insulin secretion in control subjects. But in the offspring group, this relation was absent. CONCLUSION: Our results show that both insulin resistance and impaired insulin secretion contribute to the development of type 2. DM in Koreans. In addifion, diabetic subjects had more severe impairment in insulin secretory capacity than insulin resistance.

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