Skip Navigation
Skip to contents

Diabetes Metab J : Diabetes & Metabolism Journal

Search
OPEN ACCESS

Articles

Page Path
HOME > Diabetes Metab J > Volume 30(2); 2006 > Article
Original Article Effects of Pioglitazone on Cerebral Hemodynamics in Patients of Type 2 Diabetes.
Jong Suk Park, You Jung Lee, Chul Sik Kim, Hai Jin Kim, Jina Park, Chul Woo Ahn, Kyung Yul Lee, Hyeong Jin Kim, Young Jun Won, Hun Ju Ha, Hae Sun Kwak, Bong Soo Cha, Sung Kil Lim, Kyung Rae Kim, Hyun Chul Lee
Diabetes & Metabolism Journal 2006;30(2):96-103
DOI: https://doi.org/10.4093/jkda.2006.30.2.96
Published online: March 1, 2006
  • 2,589 Views
  • 18 Download
  • 0 Crossref
  • 0 Scopus
1Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
2Ewha Graduate School of Clinical Health Science, Seoul, Korea.
3Department of Neurology, Yonsei University College of Medicine, Seoul, Korea.
4Department of Internal Medicine, Kwandong University College of Medicine, Gangneung, Korea.

BACKGROUND
Atherosclerosis is one of the major causes of morbidity and mortality in patients with type 2 diabetes and pioglitazone has been reported to have antiatherogenic effect. The aim of this study was to investigate whether pioglitazone affects carotid intima-media thickness (IMT) and pulsatility index (PI) in type 2 diabetic patients. METHODS: A total of 40 type 2 diabetic patients were included and divided into two groups: the pioglitazone-treated group (pioglitazone 15 mg/day with gliclazide 80~320 mg/day for 12 weeks) (n = 20) and control group (gliclazide 80~320 mg/day for 12 weeks) (n = 20). The changes in lipid profile, insulin resistance, IMT, and PI were monitored to determine that pioglitazone improves cerebrovascular blood flow. RESULTS: The pioglitazone treatment significantly increased HDL-C, reduced triglyceride, insulin resistance and PI. IMT tended to decrease but the change was not significant. This study revealed that treatment with pioglitazone was associated with the improvement of cerebrovascular blood flow. CONCLUSIONS: Pioglitazone appears to be effective for the improvement of cerebrovascular blood flow in type 2 diabetic patients

  • Cite
    CITE
    export Copy
    Close
    Download Citation
    Download a citation file in RIS format that can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Reference Manager.

    Format:
    • RIS — For EndNote, ProCite, RefWorks, and most other reference management software
    • BibTeX — For JabRef, BibDesk, and other BibTeX-specific software
    Include:
    • Citation for the content below
    Effects of Pioglitazone on Cerebral Hemodynamics in Patients of Type 2 Diabetes.
    Korean Diabetes J. 2006;30(2):96-103.   Published online March 1, 2006
    Close
Related articles

Diabetes Metab J : Diabetes & Metabolism Journal