Skip Navigation
Skip to contents

Diabetes Metab J : Diabetes & Metabolism Journal

Search
OPEN ACCESS

Articles

Page Path
HOME > Diabetes Metab J > Volume 26(2); 2002 > Article
Original Article Therapeutic Effect of Amomum xanthoides Extract on Experimental Diabetes Induced by Alloxan.
Hye Won Rho, Jina Lee, Bon Sun Koo, Zheng Lim Zhao, Jin Woo Park, Hyung Rho Kim
Diabetes & Metabolism Journal 2002;26(2):126-133
DOI: https://doi.org/
Published online: April 1, 2002
  • 773 Views
  • 17 Download
  • 0 Crossref
  • 0 Scopus
Department of Biochemistry, School of Medicine and Institute for Medical Science, Chonbuk National University, Chonju, Korea.

BACKGROUND
During the screening of natural products for potential anti- diabetogenic components, a strong protective effect of Amomum xanthoides extract on alloxan-induced beta-cell damage and in a mice diabetic model. In this study, the therapeutic effect of Amomum xanthoides extract was investigated after induction of diabetes by alloxan. METHODS: Experimental diabetes was induced by the injection of alloxan (60 mg/kg) to the mouse via the tail vein. To examine the effect the of Amomum xanthoides extract on diabetes, Amomum xanthoides extract (2.5 mg/mouse) was admini- strated intraperitoneally. The effect of the Amomum xanthoides extract on alloxan- induced diabetes was observed by measuring the blood glucose and serum insulin level, and a histological examination. RESULTS: Alloxan caused hyperglycemia and hypoinsulinemia by a selectively destroying pancreatic beta-cell. Pretreating the with an Amomum xanthoides extract completely protected them from the hyperglycemia induced by alloxan. In addition, the Amomum xanthoides extract administe 3 days after the of alloxan injection significantly abolished the hyperglycemia and hypoinsulinemia induced by alloxan. the alloxan-treated mice showed a marked change of in the pancreatic islets: the number of islets was reduced and the size of the remaining islets also decreased. However these effects of alloxan were significantly recovered by a later administration of the Amomum xanthoides extract. CONCLUSION: The amomum xanthoides extract contains potentially effective components, which both protect and treat alloxan-induced diabetes. The identification and action mechanism of the effective components of the Amomum xanthoides extract requires further investigation and it is suggested that the Amomum xanthoides extract be used as a therapeutic drug for diabetes.

  • Cite
    CITE
    export Copy
    Close
    Download Citation
    Download a citation file in RIS format that can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Reference Manager.

    Format:
    • RIS — For EndNote, ProCite, RefWorks, and most other reference management software
    • BibTeX — For JabRef, BibDesk, and other BibTeX-specific software
    Include:
    • Citation for the content below
    Therapeutic Effect of Amomum xanthoides Extract on Experimental Diabetes Induced by Alloxan.
    Korean Diabetes J. 2002;26(2):126-133.   Published online April 1, 2002
    Close
Related articles

Diabetes Metab J : Diabetes & Metabolism Journal