INTRODUCTION

Physical function describes the ability of an individual to undertake different physical tasks in daily living and is considered an important indicator of body performance [1,2]. Objective-measures of physical function, which in general includes grip strength, walking speed, and standing balance, declines with aging, leading to increased risks of disability and frailty [3,4]. Moreover, population-based studies have shown that in older adults, a decline in physical function is also predictive of future cardiovascular events and all-cause mortality [1,5]. Maintaining adequately functioning physical function or preventing declines in physical function is therefore of significant importance in promoting healthy aging.

Prediabetes is a common metabolic disorder during aging, which affects approximately one-half of the United States and the Chinese adults aged >50 years [6,7]. In a recent longitudinal study enrolling 2,013 older adults from the Swedish National Study on Aging and Care in Kungsholmen, individuals with prediabetes exhibited more rapid declines in chair-rising time (a measure for muscle strength) and walking speed than those with normoglycemia [8], underscoring the importance to assess physical function in the aging population with prediabetes as a clinical routine.

However, prediabetes is an intermediate dysglycemic status, which may either progress to diabetes, remain unchanged, or regress to normoglycemia during its natural history [9,10]. While previous studies have suggested that prediabetes progression predisposes individuals to increased risks of cardiovascular and all-cause mortality [11], and that prediabetes regression lowers the risks of cardiovascular events [12], the impact of prediabetes progression or regression on physical function remains unknown. To fill in these gaps, we conducted this study in community-dwellers with prediabetes aged >50 years based on the Health and Retirement Study (HRS) that had a prospective cohort design [13], wherein physical function was objectively-measured by grip strength, timed walking, and standing tests.

METHODS

Study participants

HRS is an ongoing longitudinal survey of nationally representative community-dwellers aged >50 years in United States that is sponsored by the National Institute on Aging (grant number NIA U01AG009740) and is conducted by the University of Michigan [13], and its design is detailed on http://hrsonline.isr.umich.edu/. Since 2006, one-half of the HRS participants were randomly selected for an enhanced face-to-face interview, which included measurements of physical function and blood biomarkers, with the remaining (the other one-half of participants in 2006 survey) completing the same interview in 2008 [14]. This rotation design had continued for all the following biennial HRS surveys, resulting in a 4-year time-window for the periodic follow-up on the measures of physical function and blood biomarkers. The protocol of HRS was approved by the Institutional Review Board at the University of Michigan (approved no. HUM00061128). All respondents in HRS had provided written informed consent. The present study was conducted according to the guideline of Strengthening the Reporting of Observational Studies in Epidemiology.

Considering the 4-year turn-around time as aforementioned and to increase statistical power, we created three sequential datasets based on the HRS surveys, namely the pre-evaluation (data combined from 2008 and 2010 waves), baseline (data combined from 2012 and 2014 waves), and follow-up (data combined from 2016 and 2018 waves) datasets. For them, the preevaluation dataset was used to identify participants with prediabetes, the baseline dataset was to ascertain prediabetes status alteration (that is, prediabetes progression, regression, and maintenance), and the follow-up dataset was to assess the impact of prediabetes status alteration on physical function (Fig. 1A).

Following this design, and after excluding participants with normoglycemia or diabetes in the pre-evaluation dataset or those with incomplete data on glycosylated hemoglobin (HbA1c) to ascertain prediabetes or prediabetes status alteration in the baseline or follow-up datasets, we included 1,511 participants aged >50 years, who were identified as prediabetes in the pre-evaluation dataset. The detailed selection process is described in Fig. 1B.

Covariables

Since prediabetes status alteration was determined in the baseline dataset and given our aim was to assess the association of prediabetes status alteration on physical function, the following covariables in the baseline dataset were included in the analysis.

Demographic data (age and sex), lifestyle message (history of drinking and smoking and physical exercise), and health conditions (history of diabetes, chronic lung disease, arthritis, and Alzheimer’s disease) were obtained by questionnaires. Anthropometric parameters including body weight and height were measured, and body mass index (BMI) was calculated as weight divided by the square of height (kg/m²). Systolic and diastolic blood pressure were recorded as averages of three measurements at rest.

Biomarkers including HbA1c, total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), and C-reactive protein (CRP) were measured using dried blood spot samples These biomarker data were calibrated against the whole-blood assays, and the transformed scores were employed for the present study [15]. Missing data on blood pressure, BMI, TC, HDL-C, and CRP in the baseline dataset were imputed using the Markov Chain Monte Carlo method.

Measurement of physical function

Grip strength: assessed using the hand dynamometers

Two measurements were performed for each hand, and the averages from the dominant hand were used. Grip strength was analyzed as both: (1) a binary variable categorized as with or without weak grip strength (cut-offs: <26 kg for men and <16 kg for women) [3,16], and (2) a continuous variable.

Walking speed: assessed using a timed walking test

Participants were asked to walk 2.5 m at the usual pace two times, with the walking time being recorded. Walking speed was analyzed as both: (1) a binary variable as with or without slow walking speed (cut-off: <0.8 m/sec) [3], and (2) a continuous variable.

Standing balance: assessed by the semi-tandem, side-by-side, and full-tandem standing tests

Participants were asked to perform the semi-tandem standing test [13]. If failed, they were asked to perform the side-by-side standing test; or if succeeded, to perform the full-tandem standing test. Standing balance was considered a binary variable and was categorized as with or without poor standing balance (that is, an uncompleted full-tandem standing test).

Changes in grip strength and walking speed were calculated as the follow-up scores minus the baseline scores.

Definition of prediabetes status alteration

The classifications of prediabetes, diabetes, and normoglycemia were defined based on the American Diabetes Association criteria: prediabetes: HbA1c 5.7% to 6.4% (39 to 47 mmol/mol); diabetes: HbA1c ≥6.5% (48 mmol/mol), and/or self-reported history (including the use of anti-diabetes medications); and normoglycemia: HbA1c <5.7% (39 mmol/mol) [17]. In the baseline dataset, we referred prediabetes maintenance to participants who maintained as prediabetes from preevaluation dataset, prediabetes progression to participants who progressed to diabetes from prediabetes, and prediabetes regression to participants who regressed to normoglycemia from prediabetes.

Statistical analysis

Differences in baseline characteristics were compared using chi-square test for categorical variables and independent t-tests for continuous variables. Logistic and linear regression analyses were conducted to estimate the odds ratios (ORs) and 95% confidence intervals (CIs) of developing impaired physical function (including weak grip strength, slow walking speed, or poor standing balance) at follow-up and to assess the associations of the mean changes in physical function related to prediabetes progression or regression compared with prediabetes maintenance, respectively, in participants without impaired physical function. For these analyses, three models were employed: model 1 including only prediabetes status alteration; model 2 adjusted for age, sex, and BMI; and model 3 additionally adjusted for history of smoking and drinking (yes or no), taking physical exercise (yes or no), history of chronic lung disease, arthritis, and Alzheimer’s disease (with or without), diastolic blood pressure, HbA1c, TC/HDL-C, CRP, and the corresponding measures of physical function.

We also performed several sensitivity analyses: (1) defining prediabetes using the International Expert Committee criterion (HbA1c 6.0% to 6.4% [42 to 47 mmol/mol]); (2) using different cut-off points for ascertaining low grip strength (<32 kg for men and <20 kg for women) [16,18] or slow walking speed (<0.6 m/sec) [16]; (3) excluding participants with data imputation; (4) excluding participants developed diabetes at follow-up; and (5) restricting participants to those who maintained glycemic status unchanged during the follow-up from the baseline dataset.

Data analyses were conducted from June 11, 2021 to February 21, 2022. All the analyses were performed using Stata version 14.0 (StataCorp LP, College Station, TX, USA), with P<0.05 considered statistically significant.

RESULTS

Characteristics of study participants at baseline

A total of 1,511 prediabetes participants from the pre-evaluation dataset were included. Of them, 700 participants maintained as prediabetes, 306 progressed to diabetes, and 505 regressed to normoglycemia after 4-year follow-up (in the baseline dataset). Upon the exclusion of participants with impaired physical function in the baseline dataset (Fig. 1B), there were 1,227 participants with adequately functioning grip strength (that is, without low grip strength), 406 with adequately functioning walking speed (that is, without slow walking speed), and 961 with adequately functioning standing balance (that is, without poor standing balance). Their characteristics are shown in Supplementary Table 1. During the 4-year follow-up, 151, 209, and 274 participants developed weak grip strength, slow walking speed, and poor standing balance, respectively.

Moreover, after the 4-year follow-up (in the follow-up dataset), 863 participants provided sufficient data to ascertain glycemic status (Supplementary Table 2). Among them, participants who maintained as prediabetes in the baseline dataset had a higher percentage of developing diabetes but a lower percentage of returning to normoglycemia compared with those who regressed to normoglycemia (35.1% vs. 10.7%, P<0.001; and 19.7% vs. 48.9%, P<0.001; respectively).

Prediabetes progression and regression on grip strength over 4 years

In comparison with participants who did not develop weak grip strength, those who developed (n=151) were older, had lower diastolic blood pressure, and were less likely to smoke and perform physical exercise (all P≤0.03) (Table 1). Using prediabetes maintenance as the reference, prediabetes progression was not associated with increased odds of developing weak muscle strength in model 1 or 2 (Table 2). However, this association became significant in the multivariable model (OR, 1.89; 95% CI, 1.04 to 3.44, model 3). Grip strength was declined during the 4-year follow-up from the baseline dataset, regardless of prediabetes status alteration (all P<0.001) (Table 3). Prediabetes progression was also associated with larger declines in grip strength compared with prediabetes maintenance (mean change: –3.47 kg vs. –2.75 kg, P<0.05 for model 3). However, prediabetes regression was not associated with decreased odds of developing weak grip strength or smaller declines in grip strength in any model (Tables 2 and 3).

Prediabetes progression and regression on walking speed over 4 years

Participants who developed slow walking speed (n=209) were older and had higher levels of CRP than those who did not develop during the 4-year follow-up (both P≤0.05) (Table 1). Walking speed was declined during the 4-year follow-up from the baseline dataset, regardless of prediabetes status alteration (all P<0.001) (Table 3). However, neither prediabetes progression nor prediabetes regression were associated with the odds of developing slow walking speed or causing any changes in walking speed in any model, compared with prediabetes maintenance (Tables 2 and 3).

Prediabetes progression and regression on standing balance over 4 years

Participants who developed poor standing balance (n=274) had older age and higher levels of CRP, and were less likely to perform physical exercise than those who did not develop during the 4-year follow-up (all P≤0.001) (Table 1). Neither prediabetes progression nor prediabetes regression were associated with the odds of developing poor standing balance, compared with prediabetes maintenance (Table 2).

Sensitivity analyses on physical function over 4 years

Using HbA1c 6.0% to 6.4% (42 to 47 mmol/mol) from the International Expert Committee criterion to diagnose prediabetes, or employing different cut-offs to define weak grip strength or slow walking speed, did not significantly affect the associations of prediabetes progression or regression with physical function in all models during the 4-year follow-up (Supplementary Tables 3 and 4), compared with the primary analyses. These associations remained generally unchanged, after excluding participants with missing information (Supplementary Table 5), or those developed diabetes during the 4-year follow-up (Supplementary Table 6). Yet prediabetes progression was not associated with weak muscle strength when restricting participants to those who maintained glycemic status unchanged during the follow-up from the baseline dataset (Supplementary Table 7).

DISCUSSION

Main findings

Our study showed for the first time in the aging population with prediabetes that: (1) prediabetes progression was associated with increased odds of developing weak grip strength and greater declines in grip strength, but unrelated to impairments in walking speed or standing balance, compared with prediabetes maintenance; and (2) prediabetes regression was not related to any changes in physical function and might be not able to prevent the declines in physical function due to aging.

Interpretations and implications

Previous studies have extensively explored the associations of impairments in physical function with poor health outcomes such as sarcopenia and disability [1,19], and the determinants underling impaired physical function in older adults [20]. However, no studies have assessed the impacts of prediabetes status alteration on physical function in an aging population. Extending from a prior observation that prediabetes, as opposed to normoglycemia, predisposes to a faster decline in chair-rising time and walking speed than normoglycemia [8], our study showed that prediabetes progression resulted in a greater reduction in grip strength by 0.8 kg and increased odds of developing weak grip strength by 89% in adults aged >50 years during the 4-year follow-up, compared with prediabetes maintenance. This indicates that prediabetes progression may accelerate the declines in muscle strength. On the basis of the currently available evidence [21-23], the association of prediabetes progression with weak grip strength may have been accounted for by elevated blood pressure, deteriorated lipid profiles, and increased body weight.

However, we did not show sufficient evidence that prediabetes progression was related to decreased odds of developing low walking speed or poor standing balance. This discrepancy is in line with the association of cardiometabolic health (which is also linked to prediabetes progression [24]) with upper limb muscle strength (reflected by grip strength), but not with lower limb muscle strength (e.g., walking speed and standing balance [25]) [26]. Although the non-significant outcomes on walking speed or standing balance may be attributable to the small sample size, particularly for the data on walking speed, it is plausible that grip strength might outperform other measures of physical function in reflecting changes in physical function in the aging population.

Of note, our study showed that prediabetes regression was not associated with any decreased odds of developing impaired physical function or could prevent declines in any objectively-measured physical function during the follow-up. Although the probability of regression to normoglycemia is significantly higher than that of progression to diabetes in prediabetes participants in the natural history [9], this does not necessary mean that promoting prediabetes regression is of limited value, in particular considering the findings that prediabetes regression is associated with reduced odds of future cardiovascular events and death [12]. It should be noted that prediabetes regression in our study occurred without intentional interventions, such as the use of metformin and exercise [24]. The modest improvements in glycemia without deliberate interventions may be insufficient to achieve significant benefits on physical function. Moreover, prediabetes was ascertained based on a single HbA1c (in the absence of blood glucose levels), which might be inadequate to fully elucidate the health benefits of prediabetes regression. It is also possible that the follow-up duration (only 4 years) for detecting differences in physical function resulted from prediabetes regression in our study might be too short. Accordingly, future studies assessing the effects of prediabetes regression by intentional interventions (e.g., metformin use [23]) or by HbA1c-plus glucose-based definitions, on physical function, with a longer follow-up duration, in older adults are therefore warranted.

Our study analyzed the association of prediabetes progression and regression on physical function, with prediabetes progression and regression ascertained in the baseline dataset from the pre-evaluation dataset. However, glycemic status would be subject to further changes during the follow-up. In our study we found that participants with prediabetes who once regressed to normoglycemia had a lower percentage of developing diabetes and a higher percentage of returning to normoglycemia during the follow-up, compared with participants who consistently maintained as prediabetes. This is partly in line with the outcomes from prior reports [23,27], in which regression to normoglycemia was found to be associated with reduced risk of future diabetes. However, when restricting participants to those who maintained glycemic status unchanged in the follow-up dataset, we did not find that prediabetes progression was significantly associated with weak muscle strength. This may reflect a type II error due to the small sample size in this sub-dataset and therefore a lack of sufficient statistical power (Supplementary Table 7).

Strengths and limitations

The strengths of our study include the longitudinal design with a diverse and national sample of United States adults aged >50 years, the repeated and objective measurements of different physical function, and the robustness of our main results evidenced by a series of sensitivity analyses. However, several limitations should be noted while interpreting our study findings. First, the glycemic status of participants relied on the measurement of HbA1c only, the lack of fasting plasma glucose and 2-hour plasma glucose after a 75 g oral glucose in HRS might have caused underestimation of the incidence of prediabetes progression or regression. For the same reason, it was not possible to assess whether HbA1c-based prediabetes definition differs from glucose-based definition on physical function. As a result, the observed effects may be subject to unobserved confounding factors. Second, the diagnostic cut-off point of HbA1c on prediabetes remains controversial; for example, the International Expert Committee suggests a range of 6.0% to 6.4% (42 to 47 mmol/mol) rather than 5.7% to 6.4% (39 to 47 mmol/mol) from the American Diabetes Association [26,28]. However, our sensitivity analysis (Supplementary Table 3) indicated that this discrepancy was unlikely to influence our study conclusions. Third, specific cut-off points in defining impaired physical function remain debatable [3,29], but the outcomes of our study remained robust by employing alternative cut-off points (Supplementary Table 4). Fourth, despite the effort to reduce the likelihood of reverse causality by excluding participants with suboptimal physical function at entry and controlling for covariables such as demographic parameters, lifestyle message, and blood biomarkers, the observational nature of prospective cohort studies cannot adequately ascertain the causal relationship between prediabetes progression or regression and physical function in the aging population. Finally, the sample size for the analysis on walking speed was small and the 4-year follow-up duration was relatively short, so that findings from our study might need to be validated by prospective studies with larger sample sizes and longer-term follow-ups.

Conclusions

In conclusion, prediabetes progression increased the odds of developing weak grip strength and accelerated the declines in grip strength, but prediabetes regression was unlikely to prevent any declines in physical function compared with prediabetes maintenance. Our findings support the concept of preventing prediabetes progression to promote healthy aging in adults aged >50 years and suggest that assessment of grip strength might be a highly sensitive measure to detect functional declines during aging.

SUPPLEMENTARY MATERIALS

NOTES

CONFLICTS OF INTEREST

No potential conflict of interest relevant to this article was reported.

AUTHOR CONTRIBUTIONS

Conception or design: S.Q., X.C., Z.S., T.W.

Acquisition, analysis, or interpretation of data: S.Q., Y.Z., B.X., X.C., W.C., Z.S.

Drafting the work or revising: S.Q., B.X., D.W., T.W.

Final approval of the manuscript: all authors.

FUNDING

This work was partly supported by the Aging Health Scientific Research Project in Jiangsu (grant No. LKM2022027), the Key Research Base of Philosophy and Social Sciences of Jiangsu Education Department (grant No. 2022B04), the Chinese Nursing Association (grant no. ZHKYQ202117), and the Key Research and Development Program in Jiangsu Province (grant No. BE2022828). Shanhu Qiu has been supported by the “Best Young Scholars” Fellowship from Southeast University. Tongzhi Wu is supported by a Mid-Career Fellowship from the Hospital Research Foundation. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Acknowledgements

None

Fig. 1.

Study design and flowchart. (A) Study design: considering the 4-year turn-around time in the Health and Retirement Study surveys, three sequential datasets were created, namely the pre-evaluation (data combined from 2008 and 2010 waves), baseline (data combined from 2012 and 2014 waves), and follow-up (data combined from 2016 and 2018 waves) datasets. The pre-evaluation dataset was used to identify participants with prediabetes, the baseline dataset was to ascertain prediabetes status alteration, and the follow-up dataset was to assess the impact of prediabetes status alteration on physical function. (B) Study flowchart: A total of 1,511 prediabetes participants aged >50 years from the pre-evaluation dataset were included. Among them, 1,227 participants with adequately functioning grip strength, 406 with adequately functioning walking speed, and 961 with adequately functioning standing balance were finally used for analyses on physical function during a 4-year follow-up. HbA1c, glycosylated hemoglobin.

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Figure & Data

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