Diabetes & Metabolism Journal

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Effect of Atorvastatin on Growth Differentiation Factor-15 in Patients with Type 2 Diabetes Mellitus and Dyslipidemia: Ji Min Kim, Min Kyung Back, Hyon-Seung Yi, Kyong Hye Joung, Hyun Jin Kim, Bon Jeong Ku; Diabetes Metab J. 2016;40(1):70-78. Published online February 19, 2016; DOI: https://doi.org/10.4093/dmj.2016.40.1.70

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Background

Elevated serum levels of growth differentiation factor-15 (GDF-15) are associated with type 2 diabetes. Therefore, the effects of atorvastatin on metabolic parameters and GDF-15 levels in patients with type 2 diabetes and dyslipidemia were evaluated.

Methods

In this prospective randomized trial from February 2013 to March 2014, 50 consecutive type 2 diabetic patients with a low density lipoprotein cholesterol (LDL-C) levels ≥100 mg/dL were enrolled. The patients were divided into two groups based on the amount of atorvastatin prescribed, 10 mg/day (n=23) or 40 mg/day (n=27). The effect of atorvastatin on metabolic parameters, including lipid profiles and GDF-15 levels, at baseline and after 8 weeks of treatment were compared.

Results

The baseline metabolic parameters and GDF-15 levels were not significantly different between the two groups. After 8 weeks of treatment, the total cholesterol (TC) and LDL-C levels were significantly decreased in both groups. The mean changes in TC and LDL-C levels were more significant in the 40 mg atorvastatin group. The GDF-15 level was decreased in the 10 mg atorvastatin group, from 1,460.6±874.8 to 1,451.0±770.8 pg/mL, and was increased in the 40 mg atorvastatin group, from 1,271.6±801.0 to 1,341.4±855.2 pg/mL. However, the change in the GDF-15 level was not statistically significant in the 10 or 40 mg atorvastatin group (P=0.665 and P=0.745, respectively).

Conclusion

The GDF-15 levels were not significantly changed after an 8-week treatment with atorvastatin in type 2 diabetic patients.

Citations

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The relationship of Growth differentiation factor-15 with renal damage and dyslipidemia in non-albuminuric and albuminuric Type-2 Diabetes Mellitus
Hasan Esat Yücel, Bilal İlanbey
Medical Science and Discovery.2022; 9(6): 334. CrossRef
Comparative effectiveness of statins on non-high density lipoprotein cholesterol in people with diabetes and at risk of cardiovascular disease: systematic review and network meta-analysis
Alexander Hodkinson, Dialechti Tsimpida, Evangelos Kontopantelis, Martin K Rutter, Mamas A Mamas, Maria Panagioti
BMJ.2022; : e067731. CrossRef
The Cytokine Growth Differentiation Factor-15 and Skeletal Muscle Health: Portrait of an Emerging Widely Applicable Disease Biomarker
Boel De Paepe
International Journal of Molecular Sciences.2022; 23(21): 13180. CrossRef
Biomarkers of subclinical atherosclerosis in patients with psoriasis
Hannah Kaiser, Xing Wang, Amanda Kvist-Hansen, Martin Krakauer, Peter Michael Gørtz, Benjamin D. McCauley, Lone Skov, Christine Becker, Peter Riis Hansen
Scientific Reports.2021;[Epub] CrossRef
Growth differentiation factor-15 regulates oxLDL-induced lipid homeostasis and autophagy in human macrophages
Kathrin Ackermann, Gabriel A. Bonaterra, Ralf Kinscherf, Anja Schwarz
Atherosclerosis.2019; 281: 128. CrossRef

Maternal and Neonatal Outcomes in Korean Women with Type 1 and Type 2 Diabetes: Hee-Sook Kim, Hye-Jung Jang, Jeong-Eun Park, Moon-Young Kim, Sun-Young Ko, Sung-Hoon Kim; Diabetes Metab J. 2015;39(4):316-320. Published online August 17, 2015; DOI: https://doi.org/10.4093/dmj.2015.39.4.316

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Background

The purpose of this study was to evaluate maternal and neonatal outcomes in Korean women with type 1 diabetes and type 2 diabetes.

Methods

We performed a retrospective survey of 163 pregnancies in women with type 1 diabetes (n=13) and type 2 diabetes (n=150) treated from 2003 to 2010 at Cheil General Hospital & Women's Healthcare Center, Korea. We compared maternal characteristics as well as maternal and neonatal outcomes between groups.

Results

Differences in glycosylated hemoglobin between type 1 and type 2 diabetes were not significant. Birth weight (3,501±689.6 g vs. 3,366±531.4 g) and rate of major congenital malformations (7.7% vs. 5.6%) were not significantly different. However, women with type 1 diabetes had higher rates of preeclampsia (38.5% vs. 8.2%, P=0.006), large for gestational age (LGA; 46.2% vs. 20.4%, P=0.004), macrosomia (38.5% vs. 13.4%, P=0.032), and admission for neonatal care (41.7% vs. 14.8%, P=0.03) than women with type 2 diabetes.

Conclusion

Maternal and neonatal outcomes for women with type 1 diabetes were poorer than for women with type 2 diabetes, especially preeclampsia, LGA, macrosomia and admission to the neonatal intensive care unit.

Citations

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The Impact of Type 2 Diabetes on Women’s Health and Well-being During Their Reproductive Years: A Mixed-methods Systematic Review
Aycan Celik, Rita Forde, Simona Racaru, Angus Forbes, Jackie Sturt
Current Diabetes Reviews.2022;[Epub] CrossRef
Application of the electronic nose in predicting preeclampsia in high-risk pregnancies. Pilot study
Karen Beatriz Méndez Rodríguez, Luis Manuel Ramírez Gómez, Leticia Carrizales Yáñez, Rogelio Flores Ramírez, Omar Ornelas-Rebolledo, Jaime Antonio Borjas-García, Francisco Pérez-Vázquez, Maribel Rodríguez Aguilar
Archives of Medical Research.2021;[Epub] CrossRef
Obstetric and neonatal complications among women with autoimmune disease
Andrew Williams, Katherine Grantz, Indulaxmi Seeni, Candace Robledo, Shanshan Li, Marion Ouidir, Carrie Nobles, Pauline Mendola
Journal of Autoimmunity.2019; 103: 102287. CrossRef
Effects of maternal age, parity and pre-pregnancy body mass index on the glucose challenge test and gestational diabetes mellitus
Adel T. Abu-Heija, Majeda R. Al-Bash, Moza A. Al-Kalbani
Journal of Taibah University Medical Sciences.2017; 12(4): 338. CrossRef
Deficient Vitamin E Uptake During Development Impairs Neural Tube Closure in Mice Lacking Lipoprotein Receptor SR-BI
Nicolás Santander, Carlos Lizama, María José Parga, Alonso Quiroz, Druso Pérez, Guadalupe Echeverría, Lorena Ulloa, Verónica Palma, Attilio Rigotti, Dolores Busso
Scientific Reports.2017;[Epub] CrossRef

Myeloperoxidase Is Associated with Insulin Resistance and Inflammation in Overweight Subjects with First-Degree Relatives with Type 2 Diabetes Mellitus: Anel Gómez García, Mireya Rivera Rodríguez, Carlos Gómez Alonso, Daysi Yazmin Rodríguez Ochoa, Cleto Alvarez Aguilar; Diabetes Metab J. 2015;39(1):59-65. Published online February 16, 2015; DOI: https://doi.org/10.4093/dmj.2015.39.1.59

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Background

Family history of type 2 diabetes mellitus (T2DM) is one of risk factors for that in future a subject can develop diabetes. Insulin resistance (IR) is important in the pathogenesis of T2DM. There is evidence that oxidative stress plays an important role in the etiology and/or progression of diabetes. Myeloperoxidase (MPO) participates in developing of inflammation. The objective was to investigate if MPO is associated with IR and inflammation in individuals with first-degree relatives of T2DM.

Methods

Cross-sectional study in 84 overweight individuals with family history of T2DM divided in two groups according to IR, group with IR (homeostasis model assessment [HOMA] ≥2.5; n=43) and control group (CG; HOMA <2.5; n=41). Complete clinical history and a venous blood sample were collected for measuring glucose and lipids profile, insulin, interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), MPO, glutathione reductase (GRd), glutathione peroxidase, and superoxide dismutase.

Results

MPO, TNF-α, and IL-6 were higher in patients with IR than in CG (MPO: 308.35 [190.85 to 445.42] vs. 177.35 [104.50 to 279.85], P=0.0001; TNF-α: 13.46 [10.58 to 18.88] vs. 9.39 [7.53 to 11.25], P=0.0001; IL-6: 32.93 [24.93 to 38.27] vs. 15.60 [12.93 to 26.27]; P=0.0001, respectively). MPO was associated with IR (rho de Spearman=0.362, P=0.001). In the analysis of lineal regression, MPO predicts IR (β, 0.263; t, 2.520; P=0.014). In the univariate analysis, MPO had an odds ratio of 9.880 for risk of IR (95% confidence interval, 2.647 to 36.879).

Conclusion

MPO had relation with IR and inflammation parameters in overweight subjects with first-degree relatives of T2DM. We need studies on a casual relationship and molecular mechanisms among the increased serum MPO levels, inflammation markers, and IR.

Citations

Citations to this article as recorded by

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Jayashree Vijaya Raghavan, Siddharth Jhunjhunwala
Journal of the Indian Institute of Science.2023; 103(1): 249. CrossRef
Serum Levels of Proinflammatory Biomarkers in Military Recruits with and without Metabolic Syndrome
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Salivary Alterations of Myeloperoxidase in Patients with Systemic Diseases: A Systematic Review
Kacper Nijakowski, Jakub Jankowski, Dawid Gruszczyński, Anna Surdacka
International Journal of Molecular Sciences.2023; 24(15): 12078. CrossRef
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Bilal Bashir, Safwaan Adam, Jan H. Ho, Zara Linn, Paul N. Durrington, Handrean Soran
Current Opinion in Lipidology.2023; 34(5): 221. CrossRef
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Matthew Barron, Hailey Hayes, Zachary Bice, Kirkwood Pritchard, Tammy Lyn Kindel
Nutrients.2023; 15(22): 4776. CrossRef
Functional annotation and enrichment analysis of differentially expressed serum proteins in patients with type 2 diabetes after dapagliflozin
Yan-Xue Zhao, Sarul Borjigin, Zhao-Li Yan
World Journal of Diabetes.2022; 13(3): 224. CrossRef
Hypochlorous Acid Chemistry in Mammalian Cells—Influence on Infection and Role in Various Pathologies
Celia María Curieses Andrés, José Manuel Pérez de la Lastra, Celia Andrés Juan, Francisco J. Plou, Eduardo Pérez-Lebeña
International Journal of Molecular Sciences.2022; 23(18): 10735. CrossRef
Non-Canonical Functions of Myeloperoxidase in Immune Regulation, Tissue Inflammation and Cancer
Joey S. Lockhart, Ronen Sumagin
International Journal of Molecular Sciences.2022; 23(20): 12250. CrossRef
Taurine supplementation reduces myeloperoxidase and matrix-metalloproteinase-9 levels and improves the effects of exercise in cognition and physical fitness in older women
Matheus Uba Chupel, Luciele Guerra Minuzzi, Guilherme Eustáquio Furtado, Mário Leonardo Santos, José Pedro Ferreira, Edith Filaire, Ana Maria Teixeira
Amino Acids.2021; 53(3): 333. CrossRef
Increased concentrations of myeloperoxidase in serum and serum extracellular vesicles are associated with type 2 diabetes mellitus
Lu Peng, Xinwei Li, Yu Li, Wen Zhao, Shaoping Nie, Huahui Yu, Yue Qi, Yanwen Qin, Huina Zhang
Clinica Chimica Acta.2021; 522: 70. CrossRef
Metabolic responsiveness to training depends on insulin sensitivity and protein content of exosomes in insulin-resistant males
Maria Apostolopoulou, Lucia Mastrototaro, Sonja Hartwig, Dominik Pesta, Klaus Straßburger, Elisabetta de Filippo, Tomas Jelenik, Yanislava Karusheva, Sofiya Gancheva, Daniel Markgraf, Christian Herder, K. Sreekumaran Nair, Andreas S. Reichert, Stefan Lehr
Science Advances.2021;[Epub] CrossRef
Increased Oxidative Stress in Gastric Cancer Patients and Their First-Degree Relatives: A Prospective Study from Northeastern Brazil
Manuel B. Braga-Neto, Deiziane V. S. Costa, Dulciene M. M. Queiroz, Felipe S. Maciel, Michelle S. de Oliveira, Antônio B. Viana-Junior, Flávia A. Santos, Renata F. C. Leitao, Gerly A. C. Brito, Paulo R. L. Vasconcelos, Lucia L. B. C. Braga, Ilaria Peluso
Oxidative Medicine and Cellular Longevity.2021; 2021: 1. CrossRef
Dysfunctional High-density Lipoprotein: The Role of Myeloperoxidase and Paraoxonase-1
Tiziana Bacchetti, Gianna Ferretti, Federico Carbone, Stefano Ministrini, Fabrizio Montecucco, Tannaz Jamialahmadi, Amirhossein Sahebkar
Current Medicinal Chemistry.2021; 28(14): 2842. CrossRef
Investigating the Role of Myeloperoxidase and Angiopoietin-like Protein 6 in Obesity and Diabetes
Mohammad G. Qaddoumi, Muath Alanbaei, Maha M. Hammad, Irina Al Khairi, Preethi Cherian, Arshad Channanath, Thangavel Alphonse Thanaraj, Fahd Al-Mulla, Mohamed Abu-Farha, Jehad Abubaker
Scientific Reports.2020;[Epub] CrossRef
The Effects of Type 2 Diabetes Mellitus on Organ Metabolism and the Immune System
Gholamreza Daryabor, Mohamad Reza Atashzar, Dieter Kabelitz, Seppo Meri, Kurosh Kalantar
Frontiers in Immunology.2020;[Epub] CrossRef
The Role of Myeloperoxidase in Biomolecule Modification, Chronic Inflammation, and Disease
Michael J. Davies, Clare L. Hawkins
Antioxidants & Redox Signaling.2020; 32(13): 957. CrossRef
Joint Measurements of Leukocyte Elastase and Myeloperoxidase Promote Identification of the State of Neutrophils in Diabetic Patients
Michael Alexandrovski, Soimita Suciu, Jakob Alexandrovski
BioResearch Open Access.2020; 9(1): 190. CrossRef
Expression of neutrophil elastase and myeloperoxidase mRNA in patients with newly diagnosed type 2 diabetes mellitus
Mokerroma Ferdous, Sonam C. R, Sonchita R. Mudi, Mohammad Ali, Shahana Jasmin, Mohammad Fariduddin, Sheikh M.K. Alam, M.I. Arslan, Subrata K. Biswas
Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2020; 14(2): 83. CrossRef
Pharmacological myeloperoxidase (MPO) inhibition in an obese/hypertensive mouse model attenuates obesity and liver damage, but not cardiac remodeling
Arnold Piek, Debby P. Y. Koonen, Elisabeth-Maria Schouten, Eva L. Lindtstedt, Erik Michaëlsson, Rudolf A. de Boer, Herman H. W. Silljé
Scientific Reports.2019;[Epub] CrossRef
Significance of Myeloperoxidase in the Onset of Cardiovascular Disease among Obese Children and Adolescents
Inas R El-Alameey, Hanaa H Ahmed, Rehab A Mahmoud, Sahar A. Kairy, Eman A Medany
Biomedical and Pharmacology Journal.2019; 12(04): 1647. CrossRef
Postprandial activation of leukocyte‐endothelium interaction by fatty acids in the visceral adipose tissue microcirculation
Kyle J. Preston, Inna Rom, Christine Vrakas, Gavin Landesberg, Zienab Etwebi, Sanae Muraoka, Michael Autieri, Satoru Eguchi, Rosario Scalia
The FASEB Journal.2019; 33(11): 11993. CrossRef
Myeloperoxidase as cardiovascular risk marker in pre-pubertal preterm children?
Denise O. Schoeps, Simone Holzer, Fabiola I. Suano-Souza, Sonia Hix, Fernando L.A. Fonseca, Roseli O.S. Sarni
Nutrition, Metabolism and Cardiovascular Diseases.2019; 29(12): 1345. CrossRef
Neutrophil elastase and myeloperoxidase mRNA expression in overweight and obese subjects
Mohammad Ali, Shahana Jasmin, Mohammad Fariduddin, Sheikh M. K. Alam, M. I. Arslan, Subrata K. Biswas
Molecular Biology Reports.2018; 45(5): 1245. CrossRef
Quantitative Proteomic Analysis of Hepatic Tissue of T2DM Rhesus Macaque
Tingfu Du, Shuaiyao Lu, Qinfang Jiang, Yun Li, Kaili Ma
Journal of Diabetes Research.2017; 2017: 1. CrossRef
Association of Interleukin-6 and Myeloperoxidase with Insulin Resistance in Impaired Fasting Glucose Subjects
Ashish Agarwal, Anupama Hegde, Charu Yadav, Afzal Ahmad, Poornima Ajay Manjrekar, Rukmini Mysore Srikantiah
Indian Journal of Clinical Biochemistry.2017; 32(1): 33. CrossRef
Association Between Tumor Necrosis Factor-α and Diabetic Peripheral Neuropathy in Patients with Type 2 Diabetes: a Meta-Analysis
Ze-Peng Mu, Yan-Gang Wang, Cheng-Qian Li, Wen-Shan Lv, Bin Wang, Zhao-Hai Jing, Xue-Jia Song, Yu Lun, Ming-Yue Qiu, Xiao-Long Ma
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Inter‐relation between brain‐derived neurotrophic factor and antioxidant enzymes in bipolar disorder
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Pei-Wen Zhang, Feng-Xia Chen, Di Li, Wen-Hua Ling, Hong-Hui Guo
Medicine.2015; 94(20): e758. CrossRef
Relationship between glycemic control and histochemical myeloperoxidase activity in neutrophils in patients with type 2 diabetes
Mustafa Unubol, Irfan Yavasoglu, Firuzan Kacar, Engin Guney, Imran Kurt Omurlu, Mevlut Ture, Gurhan Kadikoylu, Zahit Bolaman
Diabetology & Metabolic Syndrome.2015;[Epub] CrossRef

Genome-Wide Association Study Identifies Two Novel Loci with Sex-Specific Effects for Type 2 Diabetes Mellitus and Glycemic Traits in a Korean Population: Min Jin Go, Joo-Yeon Hwang, Tae-Joon Park, Young Jin Kim, Ji Hee Oh, Yeon-Jung Kim, Bok-Ghee Han, Bong-Jo Kim; Diabetes Metab J. 2014;38(5):375-387. Published online October 17, 2014; DOI: https://doi.org/10.4093/dmj.2014.38.5.375

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Background

Until recently, genome-wide association study (GWAS)-based findings have provided a substantial genetic contribution to type 2 diabetes mellitus (T2DM) or related glycemic traits. However, identification of allelic heterogeneity and population-specific genetic variants under consideration of potential confounding factors will be very valuable for clinical applicability. To identify novel susceptibility loci for T2DM and glycemic traits, we performed a two-stage genetic association study in a Korean population.

Methods

We performed a logistic analysis for T2DM, and the first discovery GWAS was analyzed for 1,042 cases and 2,943 controls recruited from a population-based cohort (KARE, n=8,842). The second stage, de novo replication analysis, was performed in 1,216 cases and 1,352 controls selected from an independent population-based cohort (Health 2, n=8,500). A multiple linear regression analysis for glycemic traits was further performed in a total of 14,232 nondiabetic individuals consisting of 7,696 GWAS and 6,536 replication study participants. A meta-analysis was performed on the combined results using effect size and standard errors estimated for stage 1 and 2, respectively.

Results

A combined meta-analysis for T2DM identified two new (rs11065756 and rs2074356) loci reaching genome-wide significance in CCDC63 and C12orf51 on the 12q24 region. In addition, these variants were significantly associated with fasting plasma glucose and homeostasis model assessment of β-cell function. Interestingly, two independent single nucleotide polymorphisms were associated with sex-specific stratification in this study.

Conclusion

Our study showed a strong association between T2DM and glycemic traits. We further observed that two novel loci with multiple diverse effects were highly specific to males. Taken together, these findings may provide additional insights into the clinical assessment or subclassification of disease risk in a Korean population.

Citations

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Interactions between Bitter Taste Receptor Gene Variants and Dietary Intake Are Associated with the Incidence of Type 2 Diabetes Mellitus in Middle-Aged and Older Korean Adults
Kyung Won Lee, Dayeon Shin
International Journal of Molecular Sciences.2023; 24(3): 2199. CrossRef
Evaluating machine learning-powered classification algorithms which utilize variants in the GCKR gene to predict metabolic syndrome: Tehran Cardio-metabolic Genetics Study
Mahdi Akbarzadeh, Nadia Alipour, Hamed Moheimani, Asieh Sadat Zahedi, Firoozeh Hosseini-Esfahani, Hossein Lanjanian, Fereidoun Azizi, Maryam S. Daneshpour
Journal of Translational Medicine.2022;[Epub] CrossRef
The potential effects of HECTD4 variants on fasting glucose and triglyceride levels in relation to prevalence of type 2 diabetes based on alcohol intake
Yoo Jeong Lee, Hansongyi Lee, Han Byul Jang, Min-Gyu Yoo, Sumin Im, Soo Kyung Koo, Hye-Ja Lee
Archives of Toxicology.2022; 96(9): 2487. CrossRef
Impaired fasting glucose and development of chronic kidney disease in non-diabetic population: a Mendelian randomization study
Hyoungnae Kim, Suyeon Park, Soon Hyo Kwon, Jin Seok Jeon, Dong Cheol Han, Hyunjin Noh
BMJ Open Diabetes Research & Care.2020; 8(1): e001395. CrossRef
Interactions of Habitual Coffee Consumption by Genetic Polymorphisms with the Risk of Prediabetes and Type 2 Diabetes Combined
Taiyue Jin, Jiyoung Youn, An Na Kim, Moonil Kang, Kyunga Kim, Joohon Sung, Jung Eun Lee
Nutrients.2020; 12(8): 2228. CrossRef
Genetic predisposition in type 2 diabetes: A promising approach toward a personalized management of diabetes
Mahmoud M. Sirdah, N. Scott Reading
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Association of transcription factor 7-like 2 (TCF7L2) gene polymorphism with type 2 diabetes mellitus in Chinese Korean ethnicity population
Kui-Chen Zhou, Hong-Wei Liu, Chen Wang, Yan-Jun Fu, Feng Jin
Medicine.2019; 98(5): e14288. CrossRef
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Jin-Kyu Kim, Ah-Young Lee, Jee-Hyun Kang, Byung-Yeon Yu, Seong-Ju Kim
Korean Journal of Family Medicine.2018; 39(1): 42. CrossRef
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Ho-Sun Lee, Yongkang Kim, Taesung Park
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Qiang Zhou, Bo Chen, Tianxing Ji, Miaoshan Luo, Jiandong Luo
Gene.2018; 642: 439. CrossRef
Opposite Genetic Effects of CMIP Polymorphisms on the Risk of Type 2 Diabetes and Obesity: A Family-Based Study in China
Yaying Cao, Tao Wang, Yiqun Wu, Juan Juan, Xueying Qin, Xun Tang, Tao Wu, Yonghua Hu
International Journal of Molecular Sciences.2018; 19(4): 1011. CrossRef
Type 2 Diabetes Genetic Variants and Risk of Diabetic Retinopathy
Yong He Chong, Qiao Fan, Yih Chung Tham, Alfred Gan, Shu Pei Tan, Gavin Tan, Jie Jin Wang, Paul Mitchell, Tien Yin Wong, Ching-Yu Cheng
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Juan de Toro-Martín, Benoit Arsenault, Jean-Pierre Després, Marie-Claude Vohl
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10-year trajectory of β-cell function and insulin sensitivity in the development of type 2 diabetes: a community-based prospective cohort study
Jung Hun Ohn, Soo Heon Kwak, Young Min Cho, Soo Lim, Hak Chul Jang, Kyong Soo Park, Nam H Cho
The Lancet Diabetes & Endocrinology.2016; 4(1): 27. CrossRef
Sex and Gender Differences in Risk, Pathophysiology and Complications of Type 2 Diabetes Mellitus
Alexandra Kautzky-Willer, Jürgen Harreiter, Giovanni Pacini
Endocrine Reviews.2016; 37(3): 278. CrossRef
No Interaction with Alcohol Consumption, but Independent Effect of C12orf51 (HECTD4) on Type 2 Diabetes Mellitus in Korean Adults Aged 40-69 Years: The KoGES_Ansan and Ansung Study
Jihye Kim, Bermseok Oh, Ji Eun Lim, Mi Kyung Kim, C. Mary Schooling
PLOS ONE.2016; 11(2): e0149321. CrossRef
Risk Prediction Using Genome-Wide Association Studies on Type 2 Diabetes
Sungkyoung Choi, Sunghwan Bae, Taesung Park
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Analysis of multiple related phenotypes in genome-wide association studies
Sohee Oh, Iksoo Huh, Seung Yeoun Lee, Taesung Park
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Recent progress in genetic and epigenetic research on type 2 diabetes
Soo Heon Kwak, Kyong Soo Park
Experimental & Molecular Medicine.2016; 48(3): e220. CrossRef
Statistical power considerations in genotype-based recall randomized controlled trials
Naeimeh Atabaki-Pasdar, Mattias Ohlsson, Dmitry Shungin, Azra Kurbasic, Erik Ingelsson, Ewan R. Pearson, Ashfaq Ali, Paul W. Franks
Scientific Reports.2016;[Epub] CrossRef
The role of vitamin D, obesity and physical exercise in regulation of glycemia in Type 2 Diabetes Mellitus patients
Abdulbari Bener, Abdulla O.A.A. Al-Hamaq, Eda Merve Kurtulus, Waleed K. Abdullatef, Mahmoud Zirie
Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2016; 10(4): 198. CrossRef
Recent advances in understanding the genetic architecture of type 2 diabetes
Karen L. Mohlke, Michael Boehnke
Human Molecular Genetics.2015; 24(R1): R85. CrossRef
Letter: Genome-Wide Association Study Identifies Two Novel Loci with Sex-Specific Effects for Type 2 Diabetes Mellitus and Glycemic Traits in a Korean Population (Diabetes Metab J2014;38:375-87)
Soo Heon Kwak
Diabetes & Metabolism Journal.2014; 38(6): 484. CrossRef
Response: Genome-Wide Association Study Identifies Two Novel Loci with Sex-Specific Effects for Type 2 Diabetes Mellitus and Glycemic Traits in a Korean Population (Diabetes Metab J2014;38:375-87)
Min Jin Go, Bong-Jo Kim
Diabetes & Metabolism Journal.2014; 38(6): 487. CrossRef

The Effects of Resistance Training on Muscle and Body Fat Mass and Muscle Strength in Type 2 Diabetic Women: Hwi Ryun Kwon, Kyung Ah Han, Yun Hyi Ku, Hee Jung Ahn, Bo-Kyung Koo, Ho Chul Kim, Kyung Wan Min; Korean Diabetes J. 2010;34(2):101-110. Published online April 30, 2010; DOI: https://doi.org/10.4093/kdj.2010.34.2.101

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Background

Our goal was to investigate the effects of low intensity resistance training on body fat, muscle mass and strength, cardiovascular fitness, and insulin sensitivity in type 2 diabetes.

Methods

Twenty-eight overweight women with type 2 diabetes were randomly assigned to a resistance training group (RG, n = 13) or a control group (CG, n = 15). RG performed resistance training using elastic bands, of which strength was equal to 40 to 50% of one repetition maximum (1RM), for three days per week. Each exercise consisted of three sets for 60 minutes. We assessed abdominal fat using computed tomography, muscle mass using dual-energy X-ray absorptiometry, and muscle strength using Keiser's chest and leg press. Insulin sensitivity was measured using the insulin tolerance test, and aerobic capacity was expressed as oxygen uptake at the anaerobic threshold (AT-VO₂) before and after the 12-week exercise program.

Results

The age of participants was 56.4 ± 7.1 years, duration of diabetes was 5.9 ± 5.5 years, and BMI was 27.4 ± 2.5 kg/m², without significant differences between two groups. During intervention, a greater increase in muscle mass and greater decreases in both total fat mass and abdominal fat were observed in RG compared to those of CG (P = 0.015, P = 0.011, P = 0.010, respectively). Increase in 1RM of upper and lower extremities was observed in the RG (P = 0.004, P = 0.040, respectively), without changes in AT-VO₂ and insulin resistance in either group.

Conclusion

In conclusion, the low intensity resistance training was effective in increasing muscle mass and strength and reducing total fat mass without change of insulin sensitivity in type 2 diabetic patients.

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Randomized Controlled Trial

The Effects of Low-Calorie Diets on Abdominal Visceral Fat, Muscle Mass, and Dietary Quality in Obese Type 2 Diabetic Subjects.: Hee Jung Ahn, Youn Ok Cho, Hwi Ryun Kwon, Yun Hyi Ku, Bo Kyung Koo, Kyung Ah Han, Kyung Wan Min; Korean Diabetes J. 2009;33(6):526-536. Published online December 1, 2009; DOI: https://doi.org/10.4093/kdj.2009.33.6.526

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Abstract PDF

BACKGROUND
Weight loss through low-calorie diets (LCDs) decreases visceral fat (VF). However, the effects on muscle mass, changes of dietary quality, and insulin sensitivity are unknown for Korean obese type 2 diabetic subjects. Therefore, this study examined such effects of LCDs. METHODS: A total of 30 obese type 2 diabetic subjects (body mass index, 27.0 +/- 2.2 kg/m2) were randomly assigned to an LCD or control group. Subjects on LCDs took 500~1,000 kcal fewer energy than their usual dietary intake (1,000~1,500 kcal/day) over the course of 12 weeks. The abdominal VF and femoral muscle mass were evaluated by computed tomography, and insulin sensitivity was assessed using an insulin tolerance test (Kitt; rate constant for plasma glucose disappearance, %/min). Dietary nutrient intake consumed by subjects was assessed by 3-day food records. RESULTS: The percent VF reduction was -23.4 +/- 17.2% in the LCD group and -9.8 +/- 11.8% in the control group after 12 weeks (P < 0.001, P = 0.002). However, significant decrease in femoral mass or proportional change of marcronutrient intake and mean adequacy ratio were not found in the LCD group, as compared to the control group. Insulin sensitivity improved in the LCD group, as compared to the control group (P = 0.040). CONCLUSION: LCD effectively improved insulin sensitivity and reduced abdominal VF without reduction of femoral muscle and dietary quality in obese type 2 diabetic subjects.

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Original Article

Relationship of Maximal Muscle Strength with Body Mass Index and Aerobics Capacity in Type 2 Diabetic Patients.: Hwi Ryun Kwon, Kyung Ah Han, Yun Hyi Ku, Hee Jung Ahn, Bo Kyung Koo, Kyung Wan Min; Korean Diabetes J. 2009;33(6):511-517. Published online December 1, 2009; DOI: https://doi.org/10.4093/kdj.2009.33.6.511

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Abstract PDF

BACKGROUND
Combination fitness regimens (including aerobic and resistance exercises) are effective for improving cardio-respiratory fitness, reducing visceral fat and increasing insulin sensitivity in diabetic patients. The combination exercise intensity that a patient is capable of is limited by his or her aerobic capacity and one repetition maximum (1RM). We investigated the relationships between 1RM, aerobic exercise capacity and body mass index in patients with type 2 diabetes. METHODS: A total of 177 (men: 85, women: 92) diabetic subjects with HbA1c < or = 10% were enrolled. Muscle strength and 1RM were assessed bychest press (upper body) and leg press (lower body). We assessed aerobic capacity by VO2max and muscle mass by bioimpedance analysis. RESULTS: There was no correlation between 1RM and VO2max in type 2 diabetic patients (upper: P = 0.122, lower: P = 0.138 for men, and upper: P = 0.952, lower: P = 0.570 for women). However, 1RM was significantly correlated with muscle mass both in men and women (upper: r = 0.493, P < 0.001, r = 0.315, P = 0.002 lower: r = 0.437 P < 0.001, r = 0.307, P =0.003, respectively). There was also a significant correlation between 1RM and BMI. In obese male subjects with BMI > or = 25 kg/m2, we observed a significant correlation between muscle mass and BMI (r = 0.374, P = 0.032), but this correlation was not observed in women. CONCLUSION: Clinicians treating Korean type 2 diabetic subjects should recommend resistance exercise to their patients. In particular, obese women with diabetes may receive greater benefits by increasing muscle mass through resistance exercises.

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Diabetes & Metabolism Journal.2011; 35(4): 374. CrossRef
The Effects of Aerobic/Resistance Exercise on Body Fat Mass, Muscle Strength and Endothelial Function in Korean Type 2 Diabetes mellitus Patients
Kyung Wan Min
Journal of Korean Diabetes.2011; 12(1): 6. CrossRef
The Effects of Resistance Training on Muscle and Body Fat Mass and Muscle Strength in Type 2 Diabetic Women
Hwi Ryun Kwon, Kyung Ah Han, Yun Hyi Ku, Hee Jung Ahn, Bo-Kyung Koo, Ho Chul Kim, Kyung Wan Min
Korean Diabetes Journal.2010; 34(2): 101. CrossRef

Randomized Controlled Trial

Effects of Adding omega-3 Fatty Acids to Simvastatin on Lipids, Lipoprotein Size and Subspecies in Type 2 Diabetes Mellitus with Hypertriglyceridemia.: Won Jun Kim, Chang Beom Lee, Cheol Young Park, Se Eun Park, Eun Jung Rhee, Won Young Lee, Ki Won Oh, Sung Woo Park, Dae Jung Kim, Hae Jin Kim, Seung Jin Han, Hong Keum Cho; Korean Diabetes J. 2009;33(6):494-502. Published online December 1, 2009; DOI: https://doi.org/10.4093/kdj.2009.33.6.494

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Abstract PDF: BACKGROUND
omega-3 fatty acids are known to improve lipid profiles, the distribution of lipoprotein subclasses, and secondary prevention against post-myocardial infarction. Rare reports have emerged of synergistic results of omega-3 fatty acids with simvastatin in cases of type 2 diabetes mellitus with hypertriglyceridemia. The purpose of this study was to determine the combined relationship of omega-3 fatty acids plus simvastatin on lipid, lipoprotein size and the types of subspecies. METHODS: This randomized, multi-center, comparison study evaluated eight weeks of combination therapy (omega-3 fatty acids (Omacor) 4 g/day plus simvastatin 20 mg/day) or monotherapy (simvastatin 20 mg/day) for at least six weeks in 62 diabetic patients. Subjects with a triglyceride concentration of more than 200 mg/dL were eligible for inclusion. RESULTS: No significant differences for omega-3 fatty acids + simvastatin versus simvastatin alone were observed for triglycerides (-22.7% vs. -14.3%, P = 0.292), HDL peak particle size (+2.8% vs. -0.4%, P = 0.076), LDL mean particle size (+0.4% vs -0.1%, P = 0.376) or LDL subspecies types, although the combination therapy showed a tendency toward lower triglycerides, larger HDL, and LDL particle sizes than did the monotherapy. There were no significant differences between the two groups in regard to HDL-C, LDL-C, or HbA1c levels. There were no serious adverse events and no abnormalities in the laboratory values associated with this study. CONCLUSION: omega-3 fatty acids were a safeform of treatment in hypertriglyceridemic patients with type 2 diabetes mellitus. But, regarding efficacy, a much larger sample size and longer-term follow-up may be needed to distinguish between the effects of combination therapy and monotherapy.

Original Articles

The Relationship Between Coronary Artery Calcification and Serum Apolipoprotein A-1 in Patients with Type 2 Diabetes.: Hyun Ae Seo, Yeon Kyung Choi, Jae Han Jeon, Jung Eun Lee, Ji Yun Jeong, Seong Su Moon, In Kyu Lee, Bo Wan Kim, Jung Guk Kim; Korean Diabetes J. 2009;33(6):485-493. Published online December 1, 2009; DOI: https://doi.org/10.4093/kdj.2009.33.6.485

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Abstract PDF

BACKGROUND
The incidence of type 2 diabetes mellitus is increasing annually and patient mortality is high. Coronary artery calcification is a predictor of coronary artery disease. Cardiovascular events, which are the main cause of death in type 2 diabetes patients, may be preventable by addressing risk factors associated with coronary artery calcification. We examined the relationships between coronary artery calcification, lipid profiles, and apolipoprotein levels. METHODS: We calculated the coronary calcium scores (CCS) of 254 subjects with type 2 diabetes (113 males, 141 females) via multi-detector row computed tomography (MDCT). Height, body weight, blood pressure, HbA1c, c-peptide, lipid profile and apolipoprotein were assessed concurrently. RESULTS: In patients with type 2 diabetes, Agatston score and apolipoprotein A-1 were significantly negatively correlated in both males and females (males P = 0.015, females P = 0.021). The negative correlation between Agatston score and apolipoprotein A-1 was retained for the entire patient sample after adjustments for age and sex (P = 0.022). Stepwise multiple regression anaylses with the Agatston score as the dependent variable indicate that apolipoprotein A-1 is a independent predictor (beta coefficient = -0.047, 95%CI = -0.072 ~ -0.021, P < 0.001) of coronary artery calcification. CONCLUSION: The results of our study suggest that apolipoprotein A-1 is a useful independent indicator of coronary artery calcification.

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Abstract PDF

BACKGROUND
Serum leptin level and bone mineral density (BMD) are widely assumed to be positively associated with body fat mass. Numerous attempts have been made to document the relationship between leptin and BMD, but the results are inconsistent, especially in diabetic patients. METHODS: A total of 60 Korean postmenopausal women with type 2 diabetes mellitus were included in the present study. The BMDs of lumbar spines (L1 to L4) and proximal femurs (trochanter, neck, and total) were measured by dual-energy X-ray absorptiometry (DXA), and biochemical markers including leptin, HbA1c, C-peptide and urine albumin-creatinine ratio (ACR) were measured for each patient. RESULTS: Negative associations between leptin and BMD of femoral neck, trochanter, and total femur in postmenopausal women with type 2 diabetes mellitus were documented in a model adjusted for age, body fat mass, and fasting insulin level (r = -0.308, P = 0.020 and r = - 0.303, P = 0.025 and r = - 0.290, P = 0.032 respectively). Multiple linear regression analysis was performed revealing negative associations between leptin and BMD of the femoral neck (beta = -0.369), trochanter (beta = -0.324), and total femur (beta = -0.317). CONCLUSION: The results of the present study suggest a negative relationship between leptin and femoral BMD. In addition, leptin may have a negative effect on BMD in postmenopausal women with type 2 diabetes mellitus.

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Evaluation of bone mineral density in type 2 diabetes mellitus patients before and after treatment
MK Dutta, R Pakhetra, MK Garg
Medical Journal Armed Forces India.2012; 68(1): 48. CrossRef

Maximal Muscle Strength Deteriorates with Age in Subjects with Type 2 Diabetes Mellitus.: Hwi Ryun Kwon, Yun Hyi Ku, Hee Jung Ahn, Ji Yun Jeong, Sang Ryol Ryu, Bo Kyung Koo, Kyung Ah Han, Kyung Wan Min; Korean Diabetes J. 2009;33(5):412-420. Published online October 1, 2009; DOI: https://doi.org/10.4093/kdj.2009.33.5.412

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Abstract PDF

BACKGROUND
It is difficult to improve muscle strength with only aerobic exercise training in type 2 diabetes patients. Resistance training is effective for improving muscle mass, muscle strength and insulin sensitivity. One repetition maxima (1RM), or the maximum amount of weight a subject can lift in a single repetition, may be a useful unit for evaluating the results of resistance training in type 2 diabetic patients. This study was aimed to assess baseline values for 1RM in a sample of Korean type 2 diabetes mellitus patients that are scaled for intensity and load of exercise, and to assess the relationship of 1RM to age. METHODS: A total of 266 (male: 95, female: 171) Korean patients with type 2 diabetes mellitus were included in the study sample. Maximal muscle strength was assessed by measuring 1RM for each subject (KEISER, Fresno, CA, USA). Two different exercises were used to measure 1RM: the chest press for the upper extremities, and the leg press for the lower extremities. RESULTS: Both upper and lower values of 1RM decreased with age in men and women; upper 1RM: r = -0.454, P<0.001 in men, r = -0.480, P< 0.001 in women, lower 1RM: r = -0.569, P<0.001 in men, and r = -0.452, P<0.001 in women. Values of 1RM significantly decreased in men only after the age of 70. In women, values of 1RM continuously decreased after the age of 60. CONCLUSION: The maximal muscle strength of individuals with type 2 diabetes decreases with age. We believe that resistance training is especially beneficial for type 2 diabetes mellitus patients after the sixth decade of life.

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The Effects of Floor-seated Exercise Program on Physical Fitness, Depression, and Sleep in Older Adults: A Cluster Randomized Controlled Trial
Min-Jung Choi, Kyeong-Yae Sohng
International Journal of Gerontology.2018; 12(2): 116. CrossRef
The Effects of Aerobic/Resistance Exercise on Body Fat Mass, Muscle Strength and Endothelial Function in Korean Type 2 Diabetes mellitus Patients
Kyung Wan Min
Journal of Korean Diabetes.2011; 12(1): 6. CrossRef
The Correlations between Extremity Circumferences with Total and Regional Amounts of Skeletal Muscle and Muscle Strength in Obese Women with Type 2 Diabetes
Hwi Ryun Kwon, Kyung Ah Han, Hee Jung Ahn, Jae Hyuk Lee, Gang Seo Park, Kyung Wan Min
Diabetes & Metabolism Journal.2011; 35(4): 374. CrossRef
The Effects of Resistance Training on Muscle and Body Fat Mass and Muscle Strength in Type 2 Diabetic Women
Hwi Ryun Kwon, Kyung Ah Han, Yun Hyi Ku, Hee Jung Ahn, Bo-Kyung Koo, Ho Chul Kim, Kyung Wan Min
Korean Diabetes Journal.2010; 34(2): 101. CrossRef
Relationship of Maximal Muscle Strength with Body Mass Index and Aerobics Capacity in Type 2 Diabetic Patients
Hwi Ryun Kwon, Kyung Ah Han, Yun Hyi Ku, Hee Jung Ahn, Bo Kyung Koo, Kyung Wan Min
Korean Diabetes Journal.2009; 33(6): 511. CrossRef

Randomized Controlled Trial

Effects of Aerobic Exercise Intensity on Insulin Resistance in Patients with Type 2 Diabetes Mellitus.: Yun Hyi Ku, Bo Kyung Koo, Hee Jung Ahn, Ji Yun Jeong, Hee Geum Seok, Ho Chul Kim, Kyung Ah Han, Kyung Wan Min; Korean Diabetes J. 2009;33(5):401-411. Published online October 1, 2009; DOI: https://doi.org/10.4093/kdj.2009.33.5.401

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Abstract PDF

BACKGROUND
Exercise offers protection against atherosclerosis and insulin resistance. We evaluated the benefits of exercise at different levels of intensity for ameliorating inflammation, endothelial dysfunction, and insulin resistance in a sample of type 2 diabetic subjects. METHODS: Fifty-nine overweight women with type 2 diabetes were randomly assigned to control (CG, N = 18), moderate-intensity exercise (MEG, N = 17), and vigorous-intensity exercise (VEG, N = 14) groups. Patients in the two experimental groups completed a 12-week exercise program, with their exercise activities monitored by accelerometers. We assessed the patients' body weights, total abdominal fat (TF), subcutaneous fat (SF) and visceral fat (VF) via computed tomography, measurements of plasma levels of hs-C-reactive protein (hs-CRP) and interleukin-6 (IL-6), assessment of endothelial function by brachial artery flow-mediated dilation (FMD), and evaluation of insulin sensitivity by insulin tolerance tests, at baseline, at the end of the 12-week interventions, and one year after initiation of the study. RESULTS: At baseline, the average age of all subjects was 54 +/- 7 years, and average body mass index (BMI) was 26.9 +/- 2.5 kg/m2. During the intervention, patients in the MEG and VEG groups expended comparable amounts of activity-related calories (488.6 +/- 111.9 kcal/day, 518.8 +/- 104.1 kcal/day, respectively). Although BMI, TF, and SF decreased similarly in the MEG and VEG groups (deltaBMI: -1.1 +/- 0.7, -0.8 +/- 0.5, deltaTF: -4,647 +/- 3,613 mm2, -2,577 +/- 2,872 mm2, deltaSF: -2,057 +/- 2,021 mm2, -1,141 +/- 1,825 mm2, respectively), compared to control (P<0.01), hs-CRP, IL-6, and FMD remained constant in both exercise groups even after completion of the 12-week exercise intervention. Insulin sensitivity improved only in patients subjected to vigorous exercise (VEG). Visceral fat loss was observed only in patients subjected to moderate exercise (MEG). At one-year follow up, these values had all returned to baseline. CONCLUSION: Exercise vigorous enough to result in significant weight and fat reduction did not ameliorate inflammation and endothelial dysfunction as measured at the end of a 12-week exercise intervention, nor did it result in sustained improvements in insulin sensitivity in type 2 diabetic subjects.

Citations

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The anti-inflammatory effects of aerobic exercise training in patients with type 2 diabetes: A systematic review and meta-analysis
Georgia Papagianni, Chrystalla Panayiotou, Michail Vardas, Nikolaos Balaskas, Constantinos Antonopoulos, Dimitrios Tachmatzidis, Triantafyllos Didangelos, Vaia Lambadiari, Nikolaos P.E. Kadoglou
Cytokine.2023; 164: 156157. CrossRef
Effects of Exercise on Inflammatory Cytokines in Patients with Type 2 Diabetes: A Meta-analysis of Randomized Controlled Trials
Xiaoke Chen, Xinzheng Sun, Chenghao Wang, Hui He, Jos L. Quiles
Oxidative Medicine and Cellular Longevity.2020; 2020: 1. CrossRef
Effect of Diabetic Dietary Education Program on Diabetes Knowledge and Dietary Behaviors of Elderly Diabetic Patients
Ji Young Ye, Sung Hee Min, Min June Lee
Korean Journal of Food & Cookery Science.2017; 33(5): 601. CrossRef
Effect of aerobic exercise intensity on glycemic control in type 2 diabetes: a meta-analysis of head-to-head randomized trials
Yilina Liubaoerjijin, Tasuku Terada, Kevin Fletcher, Normand G. Boulé
Acta Diabetologica.2016; 53(5): 769. CrossRef
Letter: Effects of Aerobic Exercise Intensity on Insulin Resistance in Patients with Type 2 Diabetes Mellitus (Korean Diabetes J 33(5):401-411, 2009)
Dong-Lim Kim
Korean Diabetes Journal.2009; 33(6): 547. CrossRef
Response: Effects of Aerobic Exercise Intensity on Insulin Resistance in Patients with Type 2 Diabetes Mellitus (Korean Diabetes J 33:(5)401-411, 2009)
Yun Hyi Ku, Bo-Kyung Koo, Kyung-Wan Min
Korean Diabetes Journal.2009; 33(6): 549. CrossRef

Original Articles

Relationship Between Metabolic Syndrome and Risk of Chronic Complications in Koreans with Type 2 Diabetes.: Hye Soo Chung, Ji A Seo, Sin Gon Kim, Nan Hee Kim, Doo Man Kim, Choon Hee Chung, Dong seop Choi; Korean Diabetes J. 2009;33(5):392-400. Published online October 1, 2009; DOI: https://doi.org/10.4093/kdj.2009.33.5.392

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Abstract PDF

BACKGROUND
We examined the relationships between components of metabolic syndrome at the time of diagnosis of type 2 diabetes, and the development of chronic complications in Korean patients with type 2 diabetes. METHODS: The medical records of patients with type 2 diabetes who had undergone treatment for at least five years prior were collected from 10 general hospitals in Korea. Among a total of 1,418 patients reviewed for possible inclusion in this study, 603 patients were selected, and the occurrence of complications among these patients was evaluated. RESULTS: Among the 603 patients (male, 253; female, 350), 154 males (60.8%) and 266 females (76.0%) were diagnosed with metabolic syndrome at the time of initial diagnosis of type 2 diabetes. The incidence of chronic complications (average follow-up 15.2 +/- 4.9 years) included 60 cases of coronary artery disease (CAD), 57 cases of cerebrovascular accident (CVA), 268 cases of diabetic retinopathy (DR), 254 cases of diabetic nephropathy (DN), and 238 cases of diabetic peripheral neuropathy (DPN). As compared to patients without metabolic syndrome, the adjusted relative risks (95% CI) of incidental diabetic complications in patients with metabolic syndrome were 3.28 (1.40~7.71) for CAD, 2.04 (0.86~4.82) for CVA, 1.53 (1.10~2.14) for DR, 1.90 (1.29~2.80) for DN, and 1.51, (1.06~2.14) for DPN. With the addition of just one constituent of metabolic syndrome, the relative risk of developing CAD, CVD, DR, DN, and DPN increased by 2.08 (95% CI, 1.27~3.40), 1.16 (0.80~1.66), 1.09 (0.93~1.26), 1.29 (1.06~1.57) and 1.06 (0.87~1.26), respectively. CONCLUSION: Metabolic syndrome in Korean patients with type 2 diabetes increases the risk of developing both macrovascular and microvascular complications.

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COVID-19 pandemic: Effects of national lockdown on the state of health of patients with type 2 diabetes mellitus in a Moroccan population
Hamid Farhane, Majida Motrane, Fatima-Ezzahra Anaibar, Aïcha Motrane, Said Nassor Abeid, Nourdin Harich
Primary Care Diabetes.2021; 15(5): 772. CrossRef
Profil clinique du syndrome métabolique et facteurs associés à sa présence au cours du diabète de type 2 à Ouagadougou (Burkina Faso)
O. Guira, H. Tiéno, Y. Sagna, P. Mayodé, D. Yanogo, L. Zoungrana, C.-G. Kyélem, M.-T. Yaméogo, J.-Y. Drabo
Médecine des Maladies Métaboliques.2016; 10(1): 70. CrossRef
The Relationship between Metabolic Syndrome and Quality of Life in Korean Adult Women
Hyung-Su Park, Jong Park
The Journal of the Korea institute of electronic communication sciences.2013; 8(4): 639. CrossRef
Diabetes Risk Analysis Model with Personalized Food Intake Preference
So-Hye Jeon, Nam-Hyun Kim
Journal of the Korea Academia-Industrial cooperation Society.2013; 14(11): 5771. CrossRef
Comorbidity Study on Type 2 Diabetes Mellitus Using Data Mining
Hye Soon Kim, A Mi Shin, Mi Kyung Kim, Yoon Nyun Kim
The Korean Journal of Internal Medicine.2012; 27(2): 197. CrossRef
Cardio-Metabolic Features of Type 2 Diabetes Subjects Discordant in the Diagnosis of Metabolic Syndrome
Sa Rah Lee, Ying Han, Ja Won Kim, Ja Young Park, Ji Min Kim, Sunghwan Suh, Mi-Kyoung Park, Hye-Jeong Lee, Duk Kyu Kim
Diabetes & Metabolism Journal.2012; 36(5): 357. CrossRef

Genetic Association of Mitochondrial DNA Polymorphisms with Type 2 Diabetes Mellitus.: Tae Su Han, Jee Hye Choi, Jina Park, Kwang Ho Lee, Ae Ja Park; Korean Diabetes J. 2009;33(5):382-391. Published online October 1, 2009; DOI: https://doi.org/10.4093/kdj.2009.33.5.382

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Abstract PDF: BACKGROUND
Although many single nucleotide polymorphisms (SNPs) of mtDNA have been found to be associated with type 2 diabetes mellitus, the results of studies using different population samples and different methods are mixed. Therefore, we conducted a genetic association study of mtDNA SNPs and type 2 diabetes mellitus in a Korean sample and compared our results with those of studies conducted in other human populations. METHODS: A total of 298 blood samples from 147 type 2 diabetic patients and 151 normal controls were surveyed for SNPs via PCR directed sequencing. Sequencing analyses were performed using the SeqMan module of the DNASTAR program. The identified SNPs were compared to previously reported SNP lists on NCBI and V-mitoSNP. RESULTS: A total of 24 SNPs were identified in the MT-RNR2, MR-TL1 and MT-ND1 mtDNA genes in Korean type 2 diabetes mellitus patients and normal controls. The SNPs identified in the Korean sample were not closely associated with the type 2 diabetes mellitus phenotype, a significantly different result from those previously observed in European, Chinese and Japanese samples. Additionally, a haplotype and prevalence analysis could not detect any differences between the type 2 diabetes mellitus patients and normal controls. CONCLUSION: The 24 mtDNA SNPs were not associated with type 2 diabetes mellitus risk in our Korean sample. The results of the present study support the possibility that mtDNA SNPs have a differential effect on the risk of type 2 diabetes mellitus according to geographical origin.

Association Between Volume of Bowls and the Dietary Intakes in Subjects with Type 2 Diabetes.: Hee Jung Ahn, Bo Kyung Koo, Ji Yeon Jung, Hwi Ryun Kwon, Mi Yeon Chung, Yun Hyi Ku, Jin Taek Kim, Kyung Ah Han, Kyung Wan Min; Korean Diabetes J. 2009;33(4):335-343. Published online August 1, 2009; DOI: https://doi.org/10.4093/kdj.2009.33.4.335

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Abstract PDF

BACKGROUND
The results of previous studies suggest that portion size is a major factor dictating dietary energy intake. We investigated the relationship between frequencies of rice meals, bowl volumes, and dietary energy intake in a sample of patients with type 2 diabetes. METHODS: A total of 203 type 2 diabetes patients were enrolled in the study. A one-week food diary was collected from each patient and used to assess the types of meal consumed as well as the context of consumption. The volumes of the eating vessels (rice, soup and side dish bowls) used by each patient were obtained by comparisons to measuring cylinders, and dietary energy and macronutrient intake were estimated for each patient by consulting three-day dietary records. RESULTS: The mean age of the 203 subjects (male: 76, female: 127) was 53.9 +/- 9.1 years and the average body mass index (BMI) was 25.6 +/- 4.2 kg/m2. Among the subjects who ate three times per day, 96.4% consumed rice more than twice out of three meals. The median volume of rice bowls used by patients was 350 cc, of soup bowls was 530 cc and of side dish bowls was 260 cc. Portion size, as estimated by rice bowl volume, was not associated with BMI. Male subjects tended to eat out of larger rice and soup bowls (P < 0.001). Portion size was correlated with energy intake from rice (P = 0.021), but not with total energy intake (kcal/kg/day), especially in male subjects. CONCLUSION: Portion size of rice bowl was correlated with energy intake from rice, but not with total energy intake in male subjects with type 2 diabetes. To design effective meal planning methods for patients with type 2 diabetes, further prospective studies are warranted to investigate causative relationships between portion size andmetabolic conditions as well as variation by gender.

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Trends in adherence to dietary recommendations among Korean type 2 diabetes mellitus patients
Kyong Park
Nutrition Research and Practice.2015; 9(6): 658. CrossRef
Small Rice Bowl-Based Meal Plan for Energy and Marcronutrient Intake in Korean Men with Type 2 Diabetes: A Pilot Study
Hee Jung Ahn, Kyung Ah Han, Jin Young Jang, Jae Hyuk Lee, Kang Seo Park, Kyung Wan Min
Diabetes & Metabolism Journal.2011; 35(3): 273. CrossRef
Nutrients and Dish Intake by Fasting Blood Glucose Level
Jihyun Choi, Hyun-Kyung Moon
The Korean Journal of Nutrition.2010; 43(5): 463. CrossRef
Small Rice Bowl-Based Meal Plan versus Food Exchange-Based Meal Plan for Weight, Glucose and Lipid Control in Obese Type 2 Diabetic Patients
Hee-Jung Ahn, Kyung-Ah Han, Hwi-Ryun Kwon, Bo-Kyung Koo, Hyun-Jin Kim, Kang-Seo Park, Kyung-Wan Min
Korean Diabetes Journal.2010; 34(2): 86. CrossRef
The Effects of Small Sized Rice Bowl on Carbohydrate Intake and Dietary Patterns in Women with Type 2 Diabetes
Hee-Jung Ahn, Yu-Kyung Eom, Kyung-Ah Han, Hwi-Ryun Kwon, Hyun Jin Kim, Kang Seo Park, Kyung-Wan Min
Korean Diabetes Journal.2010; 34(3): 166. CrossRef
The Small Rice Bowl-Based Meal Plan was Effective at Reducing Dietary Energy Intake, Body Weight, and Blood Glucose Levels in Korean Women with Type 2 Diabetes Mellitus
Hee Jung Ahn, Kyung Ah Han, Hwi Ryun Kwon, Kyung Wan Min
Korean Diabetes Journal.2010; 34(6): 340. CrossRef

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