KDA
- Current
- Browse
- Collections
-
For contributors
- For Authors
- Instructions to authors
- Article processing charge
- e-submission
- For Reviewers
- Instructions for reviewers
- How to become a reviewer
- Best reviewers
- For Readers
- Readership
- Subscription
- Permission guidelines
- About
- Editorial policy
Search
- Page Path
- HOME > Search
- Basic Research
- Vimentin Deficiency Prevents High-Fat Diet-Induced Obesity and Insulin Resistance in Mice
- SeoYeon Kim, Inyeong Kim, Wonkyoung Cho, Goo Taeg Oh, Young Mi Park
- Diabetes Metab J. 2021;45(1):97-108. Published online June 15, 2020
- DOI: https://doi.org/10.4093/dmj.2019.0198
- 7,479 View
- 231 Download
- 15 Web of Science
- 17 Crossref
-
Graphical Abstract
Abstract
PDF
Supplementary Material
PubReader 
ePub Background Obesity and type 2 diabetes mellitus are world-wide health problems, and lack of understanding of their linking mechanism is one reason for limited treatment options. We determined if genetic deletion of vimentin, a type 3 intermediate filament, affects obesity and type 2 diabetes mellitus.
Methods We fed vimentin-null (
Vim −/−) mice and wild-type mice a high-fat diet (HFD) for 10 weeks and measured weight change, adiposity, blood lipids, and glucose. We performed intraperitoneal glucose tolerance tests and measured CD36, a major fatty acid translocase, and glucose transporter type 4 (GLUT4) in adipocytes from both groups of mice.Results Vim −/− mice fed an HFD showed less weight gain, less adiposity, improved glucose tolerance, and lower serum level of fasting glucose. However, serum triglyceride and non-esterified fatty acid levels were higher inVim −/− mice than in wild-type mice. Vimentin-null adipocytes showed 41.1% less CD36 on plasma membranes, 27% less uptake of fatty acids, and 50.3% less GLUT4, suggesting defects in intracellular trafficking of these molecules.Conclusion We concluded that vimentin deficiency prevents obesity and insulin resistance in mice fed an HFD and suggest vimentin as a central mediator linking obesity and type 2 diabetes mellitus.
-
Citations
Citations to this article as recorded by
- Extracellular Vimentin Alters Energy Metabolism And Induces Adipocyte Hypertrophy
Ji-Hae Park, Soyeon Kwon, Young Mi Park
Diabetes & Metabolism Journal.2024; 48(2): 215. CrossRef - Neutrophils display distinct post-translational modifications in response to varied pathological stimuli
Pooja Yedehalli Thimmappa, Aswathy S Nair, Sian D'silva, Anjana Aravind, Sandeep Mallya, Sreelakshmi Pathappillil Soman, Kanive Parashiva Guruprasad, Shamee Shastry, Rajesh Raju, Thottethodi Subrahmanya Keshava Prasad, Manjunath B Joshi
International Immunopharmacology.2024; 132: 111950. CrossRef - Extracellular Vesicles as Carriers of Adipokines and Their Role in Obesity
Tamara Camino, Nerea Lago-Baameiro, María Pardo
Biomedicines.2023; 11(2): 422. CrossRef - Bioinformatics and Next-Generation Data Analysis for Identification of Genes and Molecular Pathways Involved in Subjects with Diabetes and Obesity
Prashanth Ganekal, Basavaraj Vastrad, Satish Kavatagimath, Chanabasayya Vastrad, Shivakumar Kotrashetti
Medicina.2023; 59(2): 309. CrossRef - Modified Signaling of Membrane Formyl Peptide Receptors in NADPH-Oxidase Regulation in Obesity-Resistant Mice
Irina Tikhonova, Alsu Dyukina, Elvira Shaykhutdinova, Valentina Safronova
Membranes.2023; 13(3): 306. CrossRef - Plasma Cytokeratin-18 Fragment Level Reflects the Metabolic Phenotype in Obesity
Joanna Goralska, Urszula Razny, Anna Gruca, Anna Zdzienicka, Agnieszka Micek, Aldona Dembinska-Kiec, Bogdan Solnica, Malgorzata Malczewska-Malec
Biomolecules.2023; 13(4): 675. CrossRef - Blueberry and Blackberry Anthocyanins Ameliorate Metabolic Syndrome by Modulating Gut Microbiota and Short-Chain Fatty Acids Metabolism in High-Fat Diet-Fed C57BL/6J Mice
Lanlan Du, Han Lü, Yan Chen, Xiaohua Yu, Tunyu Jian, Huifang Zhao, Wenlong Wu, Xiaoqin Ding, Jian Chen, Weilin Li
Journal of Agricultural and Food Chemistry.2023; 71(40): 14649. CrossRef - An analogue of the Prolactin Releasing Peptide reduces obesity and promotes adult neurogenesis
Sara KM Jörgensen, Alena Karnošová, Simone Mazzaferro, Oliver Rowley, Hsiao-Jou Cortina Chen, Sarah J Robbins, Sarah Christofides, Florian T Merkle, Lenka Maletínská, David Petrik
EMBO Reports.2023; 25(1): 351. CrossRef - Cytoskeleton alterations in non-alcoholic fatty liver disease
João Pessoa, José Teixeira
Metabolism.2022; 128: 155115. CrossRef - Recent Advances in the Treatment of Insulin Resistance Targeting Molecular and Metabolic Pathways: Fighting a Losing Battle?
Marta Wolosowicz, Slawomir Prokopiuk, Tomasz W. Kaminski
Medicina.2022; 58(4): 472. CrossRef - Roles of vimentin in health and disease
Karen M. Ridge, John E. Eriksson, Milos Pekny, Robert D. Goldman
Genes & Development.2022; 36(7-8): 391. CrossRef - Plasma Membrane Localization of CD36 Requires Vimentin Phosphorylation; A Mechanism by Which Macrophage Vimentin Promotes Atherosclerosis
Seo Yeon Kim, Se-Jin Jeong, Ji-Hae Park, Wonkyoung Cho, Young-Ho Ahn, Youn-Hee Choi, Goo Taeg Oh, Roy L. Silverstein, Young Mi Park
Frontiers in Cardiovascular Medicine.2022;[Epub] CrossRef - Camel Proteins and Enzymes: A Growing Resource for Functional Evolution and Environmental Adaptation
Mahmoud Kandeel, Abdulla Al-Taher, Katharigatta N. Venugopala, Mohamed Marzok, Mohamed Morsy, Sreeharsha Nagaraja
Frontiers in Veterinary Science.2022;[Epub] CrossRef - Brown Adipose Tissue Sheds Extracellular Vesicles That Carry Potential Biomarkers of Metabolic and Thermogenesis Activity Which Are Affected by High Fat Diet Intervention
Tamara Camino, Nerea Lago-Baameiro, Aurelio Sueiro, Susana Belén Bravo, Iván Couto, Francisco Fernando Santos, Javier Baltar, Felipe F. Casanueva, María Pardo
International Journal of Molecular Sciences.2022; 23(18): 10826. CrossRef - Dietary tea seed saponin combined with aerobic exercise attenuated lipid metabolism and oxidative stress in mice fed a high‐fat diet (HFD)
Wenjing Cao, Keying Wang, Chanhua Liang, Yanming Su, Shuang Liu, Jiali Li, Huishan Qing, Zhen Zeng, Ling Dai, Jia‐Le Song
Journal of Food Biochemistry.2022;[Epub] CrossRef - Influence of Protein Carbonylation on Human Adipose Tissue Dysfunction in Obesity and Insulin Resistance
M. Carmen Navarro-Ruiz, M. Carmen Soler-Vázquez, Alberto Díaz-Ruiz, Juan R. Peinado, Andrea Nieto Calonge, Julia Sánchez-Ceinos, Carmen Tercero-Alcázar, Jaime López-Alcalá, Oriol A. Rangel-Zuñiga, Antonio Membrives, José López-Miranda, María M. Malagón, R
Biomedicines.2022; 10(12): 3032. CrossRef - The Role of Adipose Tissue Lipolysis in Diet-Induced Obesity: Focus on Vimentin
Eun Roh, Hye Jin Yoo
Diabetes & Metabolism Journal.2021; 45(1): 43. CrossRef
- Extracellular Vimentin Alters Energy Metabolism And Induces Adipocyte Hypertrophy
- Basic Research
- The Role of CD36 in Type 2 Diabetes Mellitus: β-Cell Dysfunction and Beyond
- Jun Sung Moon, Udayakumar Karunakaran, Elumalai Suma, Seung Min Chung, Kyu Chang Won
- Diabetes Metab J. 2020;44(2):222-233. Published online April 23, 2020
- DOI: https://doi.org/10.4093/dmj.2020.0053
- 7,524 View
- 169 Download
- 17 Web of Science
- 15 Crossref
-
Abstract
PDFPubReader
Impaired β-cell function is the key pathophysiology of type 2 diabetes mellitus, and chronic exposure of nutrient excess could lead to this tragedy. For preserving β-cell function, it is essential to understand the cause and mechanisms about the progression of β-cells failure. Glucotoxicity, lipotoxicity, and glucolipotoxicity have been suggested to be a major cause of β-cell dysfunction for decades, but not yet fully understood. Fatty acid translocase cluster determinant 36 (CD36), which is part of the free fatty acid (FFA) transporter system, has been identified in several tissues such as muscle, liver, and insulin-producing cells. Several studies have reported that induction of CD36 increases uptake of FFA in several cells, suggesting the functional interplay between glucose and FFA in terms of insulin secretion and oxidative metabolism. However, we do not currently know the regulating mechanism and physiological role of CD36 on glucolipotoxicity in pancreatic β-cells. Also, the downstream and upstream targets of CD36 related signaling have not been defined. In the present review, we will focus on the expression and function of CD36 related signaling in the pancreatic β-cells in response to hyperglycemia and hyperlipidemia (ceramide) along with the clinical studies on the association between CD36 and metabolic disorders.
-
Citations
Citations to this article as recorded by- Nrf2 inhibition regulates intracellular lipid accumulation in mouse insulinoma cells and improves insulin secretory function
Alpana Mukhuty, Samanwita Mandal, Chandrani Fouzder, Snehasis Das, Dipanjan Chattopadhyay, Tanmay Majumdar, Rakesh Kundu
Molecular and Cellular Endocrinology.2024; 581: 112112. CrossRef - CD36 gene variant rs1761667(G/A) as a biomarker in obese type 2 diabetes mellitus cases
Ashwin Kumar Shukla, Amreen Shamsad, Atar Singh Kushwah, Shalini Singh, Kauser Usman, Monisha Banerjee
Egyptian Journal of Medical Human Genetics.2024;[Epub] CrossRef - CD36 regulates macrophage and endothelial cell activation and multinucleate giant cell formation in anti neutrophil cytoplasm antibody vasculitis
Xiang Zhang, Catherine King, Alexander Dowell, Paul Moss, Lorraine Harper, Dimitrios Chanouzas, Xiong-zhong Ruan, Alan David Salama
Clinical Immunology.2024; 260: 109914. CrossRef - The association of soluble cluster of differentiation 36 with metabolic diseases: A potential biomarker and therapeutic target
Yun Li, Yaxi Chen, Xiong Z. Ruan
Pediatric Discovery.2023;[Epub] CrossRef - The role of candidate transport proteins in β‐cell long‐chain fatty acid uptake: Where are we now?
Christina Clavelo‐Farrow, Patricia Thomas
Diabetic Medicine.2023;[Epub] CrossRef - SARS-CoV-2 in the pancreas and the impaired islet function in COVID-19 patients
Ningfei Ji, Mingshun Zhang, Liang Ren, Yunyun Wang, Bicheng Hu, Jie Xiang, Yingyun Gong, Chaojie Wu, Guoqiang Qu, Wenqiu Ding, Zhiqiang Yin, Shan Li, Zhengxia Wang, Lianzheng Zhou, Xueqin Chen, Yuan Ma, Jinhai Tang, Yun Liu, Liang Liu, Mao Huang
Emerging Microbes & Infections.2022; 11(1): 1115. CrossRef - Is imaging-based muscle quantity associated with risk of diabetes? A meta-analysis of cohort studies
Shanhu Qiu, Xue Cai, Yang Yuan, Bo Xie, Zilin Sun, Tongzhi Wu
Diabetes Research and Clinical Practice.2022; 189: 109939. CrossRef - Lipotoxicity in a Vicious Cycle of Pancreatic Beta Cell Exhaustion
Vladimir Grubelnik, Jan Zmazek, Matej Završnik, Marko Marhl
Biomedicines.2022; 10(7): 1627. CrossRef - Association of cluster determinant 36, scavenger receptor class B type 1, and major facilitator superfamily domain containing the 2a genetic polymorphism with serum lipid profile in aging population with type 2 diabetes mellitus
Xixiang Wang, Xiaojun Ma, Jingjing Xu, Yujie Guo, Shaobo Zhou, Huiyan Yu, Linhong Yuan
Frontiers in Nutrition.2022;[Epub] CrossRef - CD36-Fatty Acid-Mediated Metastasis via the Bidirectional Interactions of Cancer Cells and Macrophages
Noorzaileen Eileena Zaidi, Nur Aima Hafiza Shazali, Thean-Chor Leow, Mohd Azuraidi Osman, Kamariah Ibrahim, Wan-Hee Cheng, Kok-Song Lai, Nik Mohd Afizan Nik Abd Rahman
Cells.2022; 11(22): 3556. CrossRef - The Past and Present Lives of the Intraocular Transmembrane Protein CD36
Rucui Yang, Qingping Liu, Mingzhi Zhang
Cells.2022; 12(1): 171. CrossRef - Implicating the effect of ketogenic diet as a preventive measure to obesity and diabetes mellitus
Sachin Kumar, Tapan Behl, Monika Sachdeva, Aayush Sehgal, Shilpa Kumari, Arun Kumar, Gagandeep Kaur, Harlokesh Narayan Yadav, Simona Bungau
Life Sciences.2021; 264: 118661. CrossRef - Contribution of rs3211938 polymorphism at CD36 to glucose levels, oxidized low-density lipoproteins, insulin resistance, and body mass index in Mexican mestizos with type-2 diabetes from western Mexico
Beatriz Teresita Martín-Márquez, Flavio Sandoval-Garcia, Mónica Vazquez-Del Mercado, Erika-Aurora Martínez-García, Fernanda-Isadora Corona-Meraz, Ana-Lilia Fletes-Rayas, Soraya-Amalí Zavaleta-Muñiz
Nutrición Hospitalaria.2021;[Epub] CrossRef - Investigating the association of CD36 gene polymorphisms (rs1761667 and rs1527483) with T2DM and dyslipidemia: Statistical analysis, machine learning based prediction, and meta-analysis
Ma’mon M. Hatmal, Walhan Alshaer, Ismail S. Mahmoud, Mohammad A. I. Al-Hatamleh, Hamzeh J. Al-Ameer, Omar Abuyaman, Malek Zihlif, Rohimah Mohamud, Mais Darras, Mohammad Al Shhab, Rand Abu-Raideh, Hilweh Ismail, Ali Al-Hamadi, Ali Abdelhay, Kanhaiya Singh
PLOS ONE.2021; 16(10): e0257857. CrossRef - Misregulation of Wnt Signaling Pathways at the Plasma Membrane in Brain and Metabolic Diseases
Mustafa Karabicici, Yagmur Azbazdar, Evin Iscan, Gunes Ozhan
Membranes.2021; 11(11): 844. CrossRef
- Nrf2 inhibition regulates intracellular lipid accumulation in mouse insulinoma cells and improves insulin secretory function
- Metabolic Risk/Epidemiology
- Plasma CD36 and Incident Diabetes: A Case-Cohort Study in Danish Men and Women
- Yeli Wang, Jingwen Zhu, Sarah Aroner, Kim Overvad, Tianxi Cai, Ming Yang, Anne Tjønneland, Aase Handberg, Majken K. Jensen
- Diabetes Metab J. 2020;44(1):134-142. Published online October 18, 2019
- DOI: https://doi.org/10.4093/dmj.2018.0273
- 4,273 View
- 70 Download
- 2 Web of Science
- 2 Crossref
-
Abstract
PDFSupplementary MaterialPubReader
Background Membrane CD36 is a fatty acid transporter implicated in the pathogenesis of metabolic disease. We aimed to evaluate the association between plasma CD36 levels and diabetes risk and to examine if the association was independent of adiposity among Danish population.
Methods We conducted a case-cohort study nested within the Danish Diet, Cancer and Health study among participants free of cardiovascular disease, diabetes and cancer and with blood samples and anthropometric measurements (height, weight, waist circumference, and body fat percentage) at baseline (1993 to 1997). CD36 levels were measured in 647 incident diabetes cases that occurred before December 2011 and a total of 3,515 case-cohort participants (236 cases overlap).
Results Higher plasma CD36 levels were associated with higher diabetes risk after adjusting for age, sex and other lifestyle factors. The hazard ratio (HR) comparing high versus low tertile of plasma CD36 levels was 1.36 (95% confidence interval [CI], 1.00 to 1.86). However, the association lost its significance after further adjustment for different adiposity indices such as body mass index (HR, 1.23; 95% CI, 0.87 to 1.73), waist circumference (HR, 1.21; 95% CI, 0.88 to 1.68) or body fat percentage (HR, 1.20; 95% CI, 0.86 to 1.66). Moreover, raised plasma CD36 levels were moderately associated with diabetes risk among lean participants, but the association was not present among overweight/obese individuals.
Conclusion Higher plasma CD36 levels were associated with higher diabetes risk, but the association was not independent of adiposity. In this Danish population, the association of CD36 with diabetes risk could be either mediated or confounded by adiposity.
-
Citations
Citations to this article as recorded by- The Multifunctionality of CD36 in Diabetes Mellitus and Its Complications—Update in Pathogenesis, Treatment and Monitoring
Kamila Puchałowicz, Monika Ewa Rać
Cells.2020; 9(8): 1877. CrossRef - The Role of CD36 in Type 2 Diabetes Mellitus: β-Cell Dysfunction and Beyond
Jun Sung Moon, Udayakumar Karunakaran, Elumalai Suma, Seung Min Chung, Kyu Chang Won
Diabetes & Metabolism Journal.2020; 44(2): 222. CrossRef
- The Multifunctionality of CD36 in Diabetes Mellitus and Its Complications—Update in Pathogenesis, Treatment and Monitoring
First
Prev
