Adipose tissue inflammation is considered a major contributing factor in the development of obesity-associated insulin resistance and cardiovascular diseases. However, the cause of adipose tissue inflammation is presently unclear. The role of mitochondria in white adipocytes has long been neglected because of their low abundance. However, recent evidence suggests that mitochondria are essential for maintaining metabolic homeostasis in white adipocytes. In a series of recent studies, we found that mitochondrial function in white adipocytes is essential to the synthesis of adiponectin, which is the most abundant adipokine synthesized from adipocytes, with many favorable effects on metabolism, including improvement of insulin sensitivity and reduction of atherosclerotic processes and systemic inflammation. From these results, we propose a new hypothesis that mitochondrial dysfunction in adipocytes is a primary cause of adipose tissue inflammation and compared this hypothesis with a prevailing concept that “adipose tissue hypoxia” may underlie adipose tissue dysfunction in obesity. Recent studies have emphasized the role of the mitochondrial quality control mechanism in maintaining mitochondrial function. Future studies are warranted to test whether an inadequate mitochondrial quality control mechanism is responsible for mitochondrial dysfunction in adipocytes and adipose tissue inflammation.

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• Prolonged Endurance Exercise Increases Macrophage Content and Mitochondrial Respiration in Adipose Tissue in Trained Men
  Ronni Eg Sahl, Ioanna Patsi, Mikkel Thunestvedt Hansen, Tue Rømer, Jacob Frandsen, Hanne Kruuse Rasmusen, Arthur Ingersen, Steen Seier Poulsen, Flemming Dela, Steen Larsen, Jørn Wulff Helge
  The Journal of Clinical Endocrinology & Metabolism.2024; 109(2): e799.     CrossRef
• Diabetes Mellitus, Energy Metabolism, and COVID-19
  Caterina Conte, Elisa Cipponeri, Michael Roden
  Endocrine Reviews.2024; 45(2): 281.     CrossRef
• The Role of Ion-Transporting Proteins in Human Disease
  Yoshinori Marunaka
  International Journal of Molecular Sciences.2024; 25(3): 1726.     CrossRef
• The Role of Obesity in Type 2 Diabetes Mellitus—An Overview
  Preethi Chandrasekaran, Ralf Weiskirchen
  International Journal of Molecular Sciences.2024; 25(3): 1882.     CrossRef
• The Metabolic Syndrome, a Human Disease
  Marià Alemany
  International Journal of Molecular Sciences.2024; 25(4): 2251.     CrossRef
• Inflammation‐mediated metabolic regulation in adipose tissue
  Shujie Xu, Feng Lu, Jianhua Gao, Yi Yuan
  Obesity Reviews.2024;[Epub]     CrossRef
• Sleeve Gastrectomy Reduces Oxidative Stress and Reverses Mitochondrial Dysfunction Associated with Metabolic Syndrome
  Micaela M. Rossi, Franco J. Signorini, Tomas A. Castillo, María P. Scribano Parada, Federico Moser, Maria dC Baez
  Obesity Surgery.2024;[Epub]     CrossRef
• Could very low-calorie ketogenic diets turn off low grade inflammation in obesity? Emerging evidence
  Luigi Barrea, Massimiliano Caprio, Mikiko Watanabe, Giuseppe Cammarata, Alessandra Feraco, Giovanna Muscogiuri, Ludovica Verde, Annamaria Colao, Silvia Savastano
  Critical Reviews in Food Science and Nutrition.2023; 63(26): 8320.     CrossRef
• The emergent role of mitochondrial RNA modifications in metabolic alterations
  Hatim Boughanem, Yvonne Böttcher, João Tomé‐Carneiro, María‐Carmen López de las Hazas, Alberto Dávalos, Akin Cayir, Manuel Macias‐González
  WIREs RNA.2023;[Epub]     CrossRef
• Age‐associated adipose tissue inflammation promotes monocyte chemotaxis and enhances atherosclerosis
  Jianrui Song, Diana Farris, Paola Ariza, Smriti Moorjani, Mita Varghese, Muriel Blin, Judy Chen, Daniel Tyrrell, Min Zhang, Kanakadurga Singer, Morgan Salmon, Daniel R. Goldstein
  Aging Cell.2023;[Epub]     CrossRef
• Obesity, diabetes mellitus, and cardiometabolic risk: An Obesity Medicine Association (OMA) Clinical Practice Statement (CPS) 2023
  Harold Edward Bays, Shagun Bindlish, Tiffany Lowe Clayton
  Obesity Pillars.2023; 5: 100056.     CrossRef
• A role of STING signaling in obesity-induced lung inflammation
  Yong Qi, Zhuhua Wu, Dan Chen, Li Zhu, Yunlei Yang
  International Journal of Obesity.2023; 47(4): 325.     CrossRef
• Estrogens in Adipose Tissue Physiology and Obesity-Related Dysfunction
  Alina Kuryłowicz
  Biomedicines.2023; 11(3): 690.     CrossRef
• White Adipose Tissue Dysfunction: Pathophysiology and Emergent Measurements
  Natalia Santillana, Camila Astudillo-Guerrero, Amanda D’Espessailles, Gonzalo Cruz
  Nutrients.2023; 15(7): 1722.     CrossRef
• Pleiotropic and multi-systemic actions of physical exercise on PGC-1α signaling during the aging process
  Ivo Vieira de Sousa Neto, Ana Paula Pinto, Vitor Rosetto Muñoz, Rita de Cássia Marqueti, José Rodrigo Pauli, Eduardo Rochete Ropelle, Adelino Sanchez Ramos da Silva
  Ageing Research Reviews.2023; 87: 101935.     CrossRef
• The impact of metabolic endotoxaemia on the browning process in human adipocytes
  Farah Omran, Alice M. Murphy, Awais Z. Younis, Ioannis Kyrou, Jana Vrbikova, Vojtech Hainer, Petra Sramkova, Martin Fried, Graham Ball, Gyanendra Tripathi, Sudhesh Kumar, Philip G. McTernan, Mark Christian
  BMC Medicine.2023;[Epub]     CrossRef
• Molecular Mechanisms of Obesity-Induced Development of Insulin Resistance and Promotion of Amyloid-β Accumulation: Dietary Therapy Using Weak Organic Acids via Improvement of Lowered Interstitial Fluid pH
  Yoshinori Marunaka
  Biomolecules.2023; 13(5): 779.     CrossRef
• From Obesity-Induced Low-Grade Inflammation to Lipotoxicity and Mitochondrial Dysfunction: Altered Multi-Crosstalk between Adipose Tissue and Metabolically Active Organs
  Gina Cavaliere, Fabiano Cimmino, Giovanna Trinchese, Angela Catapano, Lidia Petrella, Margherita D’Angelo, Lucio Lucchin, Maria Pina Mollica
  Antioxidants.2023; 12(6): 1172.     CrossRef
• Receptor for the Advanced Glycation End Products (RAGE) Pathway in Adipose Tissue Metabolism
  Klaudia Gutowska, Krzysztof Czajkowski, Alina Kuryłowicz
  International Journal of Molecular Sciences.2023; 24(13): 10982.     CrossRef
• Aerobic and Resistance Training Attenuate Differently Knee Joint Damage Caused by a High-Fat–High-Sucrose Diet in a Rat Model
  Nada Abughazaleh, Kevin Boldt, Jaqueline Lourdes Rios, Stela Marcia Mattiello, Kelsey H. Collins, Ruth-Anne Seerattan, Walter Herzog
  CARTILAGE.2023;[Epub]     CrossRef
• Exercise mitigates age-related metabolic diseases by improving mitochondrial dysfunction
  Dandan Jia, Zhenjun Tian, Ru Wang
  Ageing Research Reviews.2023; 91: 102087.     CrossRef
• Mitochondrial dynamics and metabolism across skin cells: implications for skin homeostasis and aging
  Ines Martic, Federica Papaccio, Barbara Bellei, Maria Cavinato
  Frontiers in Physiology.2023;[Epub]     CrossRef
• Influence of Breastfeeding on the State of Meta-Inflammation in Obesity—A Narrative Review
  Dominika Mazur, Małgorzata Satora, Anna K. Rekowska, Zuzanna Kabała, Aleksandra Łomża, Żaneta Kimber-Trojnar, Bożena Leszczyńska-Gorzelak
  Current Issues in Molecular Biology.2023; 45(11): 9003.     CrossRef
• AGER-1 Long Non-Coding RNA Levels Correlate with the Expression of the Advanced Glycosylation End-Product Receptor, a Regulator of the Inflammatory Response in Visceral Adipose Tissue of Women with Obesity and Type 2 Diabetes Mellitus
  Klaudia Gutowska, Krzysztof Koźniewski, Michał Wąsowski, Marta Izabela Jonas, Zbigniew Bartoszewicz, Wojciech Lisik, Maurycy Jonas, Artur Binda, Paweł Jaworski, Wiesław Tarnowski, Bartłomiej Noszczyk, Monika Puzianowska-Kuźnicka, Krzysztof Czajkowski, Ali
  International Journal of Molecular Sciences.2023; 24(24): 17447.     CrossRef
• Pharmacological treatment with FGF21 strongly improves plasma cholesterol metabolism to reduce atherosclerosis
  Cong Liu, Milena Schönke, Enchen Zhou, Zhuang Li, Sander Kooijman, Mariëtte R Boon, Mikael Larsson, Kristina Wallenius, Niek Dekker, Louise Barlind, Xiao-Rong Peng, Yanan Wang, Patrick C N Rensen
  Cardiovascular Research.2022; 118(2): 489.     CrossRef
• Obesity-Related Adipose Tissue Remodeling in the Light of Extracellular Mitochondria Transfer
  Simon Lecoutre, Karine Clément, Isabelle Dugail
  International Journal of Molecular Sciences.2022; 23(2): 632.     CrossRef
• IL-4 polarized human macrophage exosomes control cardiometabolic inflammation and diabetes in obesity
  Tuan Anh Phu, Martin Ng, Ngan K. Vu, Laura Bouchareychas, Robert L. Raffai
  Molecular Therapy.2022; 30(6): 2274.     CrossRef
• Insulin-inducible THRSP maintains mitochondrial function and regulates sphingolipid metabolism in human adipocytes
  Maria A. Ahonen, Marcus Höring, Van Dien Nguyen, Sami Qadri, Juuso H. Taskinen, Meghana Nagaraj, Martin Wabitsch, Pamela Fischer-Posovszky, You Zhou, Gerhard Liebisch, P. A. Nidhina Haridas, Hannele Yki-Järvinen, Vesa M. Olkkonen
  Molecular Medicine.2022;[Epub]     CrossRef
• Modulation of adipose inflammation by cellular retinoic acid-binding protein 1
  Chin-Wen Wei, Jennifer Nhieu, Yu-Lung Lin, Li-Na Wei
  International Journal of Obesity.2022; 46(10): 1759.     CrossRef
• The Role of Adipokines in Pancreatic Cancer
  Qi Wang, Huizhi Wang, Yuntao Ding, Mengtian Wan, Min Xu
  Frontiers in Oncology.2022;[Epub]     CrossRef
• Epigenetic Reprogramming of the Inflammatory Response in Obesity and Type 2 Diabetes
  Federica Zatterale, Gregory Alexander Raciti, Immacolata Prevenzano, Alessia Leone, Michele Campitelli, Veronica De Rosa, Francesco Beguinot, Luca Parrillo
  Biomolecules.2022; 12(7): 982.     CrossRef
• Cellular Metabolism and Bioenergetic Function in Human Fibroblasts and Preadipocytes of Type 2 Familial Partial Lipodystrophy
  Cristina Algieri, Chiara Bernardini, Fabiana Trombetti, Elisa Schena, Augusta Zannoni, Monica Forni, Salvatore Nesci
  International Journal of Molecular Sciences.2022; 23(15): 8659.     CrossRef
• Shared pathobiology identifies AMPK as a therapeutic target for obesity and autosomal dominant polycystic kidney disease
  Ioan-Andrei Iliuta, Xuewen Song, Lauren Pickel, Amirreza Haghighi, Ravi Retnakaran, James Scholey, Hoon-Ki Sung, Gregory R. Steinberg, York Pei
  Frontiers in Molecular Biosciences.2022;[Epub]     CrossRef
• Hypoxia as a Double-Edged Sword to Combat Obesity and Comorbidities
  Ruwen Wang, Qin Sun, Xianmin Wu, Yiyin Zhang, Xiaorui Xing, Kaiqing Lin, Yue Feng, Mingqi Wang, Yibing Wang, Ru Wang
  Cells.2022; 11(23): 3735.     CrossRef
• Macrophage and Adipocyte Mitochondrial Dysfunction in Obesity-Induced Metabolic Diseases
  Liwen Wang, Jie Hu, Haiyan Zhou
  The World Journal of Men's Health.2021; 39(4): 606.     CrossRef
• ESRRA (estrogen related receptor alpha) is a critical regulator of intestinal homeostasis through activation of autophagic flux via gut microbiota
  Sup Kim, June-Young Lee, Seul Gi Shin, Jin Kyung Kim, Prashanta Silwal, Young Jae Kim, Na-Ri Shin, Pil Soo Kim, Minho Won, Sang-Hee Lee, Soo Yeon Kim, Miwa Sasai, Masahiro Yamamoto, Jin-Man Kim, Jin-Woo Bae, Eun-Kyeong Jo
  Autophagy.2021; 17(10): 2856.     CrossRef
• GDF15 as a central mediator for integrated stress response and a promising therapeutic molecule for metabolic disorders and NASH
  Kook Hwan Kim, Myung-Shik Lee
  Biochimica et Biophysica Acta (BBA) - General Subjects.2021; 1865(3): 129834.     CrossRef
• The Influence of Obesity and Associated Fatty Acids on Placental Inflammation
  Alison J. Eastman, Rebecca E. Moore, Steven D. Townsend, Jennifer A. Gaddy, David M. Aronoff
  Clinical Therapeutics.2021; 43(2): 265.     CrossRef
• Targeting the G protein-coupled estrogen receptor (GPER) in obesity and diabetes
  Geetanjali Sharma, Eric R. Prossnitz
  Endocrine and Metabolic Science.2021; 2: 100080.     CrossRef
• Changes in Body Composition Are Associated with Metabolic Changes and the Risk of Metabolic Syndrome
  Yun Hwan Oh, Seulggie Choi, Gyeongsil Lee, Joung Sik Son, Kyae Hyung Kim, Sang Min Park
  Journal of Clinical Medicine.2021; 10(4): 745.     CrossRef
• N6-Adenosine Methylation (m6A) RNA Modification: an Emerging Role in Cardiovascular Diseases
  Ye-shi Chen, Xin-ping Ouyang, Xiao-hua Yu, Petr Novák, Le Zhou, Ping-ping He, Kai Yin
  Journal of Cardiovascular Translational Research.2021; 14(5): 857.     CrossRef
• From Metabolic Syndrome to Neurological Diseases: Role of Autophagy
  Jessica Maiuolo, Micaela Gliozzi, Vincenzo Musolino, Cristina Carresi, Federica Scarano, Saverio Nucera, Miriam Scicchitano, Francesca Bosco, Stefano Ruga, Maria Caterina Zito, Roberta Macri, Rosamaria Bulotta, Carolina Muscoli, Vincenzo Mollace
  Frontiers in Cell and Developmental Biology.2021;[Epub]     CrossRef
• Absent Exercise-Induced Improvements in Fat Oxidation in Women With Polycystic Ovary Syndrome After High-Intensity Interval Training
  Sofie Lionett, Ida Almenning Kiel, Ragnhild Røsbjørgen, Stian Lydersen, Steen Larsen, Trine Moholdt
  Frontiers in Physiology.2021;[Epub]     CrossRef
• Roles of interstitial fluid pH and weak organic acids in development and amelioration of insulin resistance
  Yoshinori Marunaka
  Biochemical Society Transactions.2021; 49(2): 715.     CrossRef
• The Role of Mitochondrial Adaptation and Metabolic Flexibility in the Pathophysiology of Obesity and Insulin Resistance: an Updated Overview
  Dimitrios Tsilingiris, Evangelia Tzeravini, Chrysi Koliaki, Maria Dalamaga, Alexander Kokkinos
  Current Obesity Reports.2021; 10(3): 191.     CrossRef
• Obesity-Related Inflammation and Endothelial Dysfunction in COVID-19: Impact on Disease Severity
  Andrea De Lorenzo, Vanessa Estato, Hugo C Castro-Faria-Neto, Eduardo Tibirica
  Journal of Inflammation Research.2021; Volume 14: 2267.     CrossRef
• Thermogenic Fat: Development, Physiological Function, and Therapeutic Potential
  Bruna B. Brandão, Ankita Poojari, Atefeh Rabiee
  International Journal of Molecular Sciences.2021; 22(11): 5906.     CrossRef
• Metabolic Syndrome in an Aging Society – Role of Oxidant-Antioxidant Imbalance and Inflammation Markers in Disentangling Atherosclerosis
  Sylwia Dziegielewska-Gesiak
  Clinical Interventions in Aging.2021; Volume 16: 1057.     CrossRef
• Recruitment and remodeling of peridroplet mitochondria in human adipose tissue
  Rebeca Acín-Perez, Anton Petcherski, Michaela Veliova, Ilan Y. Benador, Essam A. Assali, Georgia Colleluori, Saverio Cinti, Alexandra J. Brownstein, Siyouneh Baghdasarian, Masha J. Livhits, Michael W. Yeh, Karthickeyan Chella Krishnan, Laurent Vergnes, Na
  Redox Biology.2021; 46: 102087.     CrossRef
• New Insights Into Mitochondrial Dysfunction at Disease Susceptibility Loci in the Development of Type 2 Diabetes
  Hannah Maude, Winston Lau, Nikolas Maniatis, Toby Andrew
  Frontiers in Endocrinology.2021;[Epub]     CrossRef
• Effects of sleeve gastrectomy on bone mass, microstructure of femurs and bone metabolism associated serum factors in obese rats
  Ying Xue, Ran Li, Yong Zhao, Ling Li, Yun Zhou
  BMC Endocrine Disorders.2021;[Epub]     CrossRef
• The cyclin dependent kinase inhibitor Roscovitine prevents diet-induced metabolic disruption in obese mice
  Nabil Rabhi, Kathleen Desevin, Briana Noel Cortez, Ryan Hekman, Jean Z. Lin, Andrew Emili, Stephen R. Farmer
  Scientific Reports.2021;[Epub]     CrossRef
• Reliability and variation in mitochondrial respiration in human adipose tissue
  Ronni Eg Sahl, Eva Frederikke Høy Helms, Malte Schmücker, Mathias Flensted-Jensen, Arthur Ingersen, Thomas Morville, Flemming Dela, Jørn Wulff Helge, Steen Larsen
  Adipocyte.2021; 10(1): 605.     CrossRef
• Inhibition of protein tyrosine phosphatase improves mitochondrial bioenergetics and dynamics, reduces oxidative stress, and enhances adipogenic differentiation potential in metabolically impaired progenitor stem cells
  Katarzyna Kornicka-Garbowska, Lynda Bourebaba, Michael Röcken, Krzysztof Marycz
  Cell Communication and Signaling.2021;[Epub]     CrossRef
• microRNAs in Human Adipose Tissue Physiology and Dysfunction
  Alina Kurylowicz
  Cells.2021; 10(12): 3342.     CrossRef
• Aging, obese-insulin resistance, and bone remodeling
  Napatsorn Imerb, Chanisa Thonusin, Nipon Chattipakorn, Siriporn C. Chattipakorn
  Mechanisms of Ageing and Development.2020; 191: 111335.     CrossRef
• Chronic Adipose Tissue Inflammation Linking Obesity to Insulin Resistance and Type 2 Diabetes
  Federica Zatterale, Michele Longo, Jamal Naderi, Gregory Alexander Raciti, Antonella Desiderio, Claudia Miele, Francesco Beguinot
  Frontiers in Physiology.2020;[Epub]     CrossRef
• Is Mitochondrial Dysfunction a Common Root of Noncommunicable Chronic Diseases?
  Alexis Diaz-Vegas, Pablo Sanchez-Aguilera, James R Krycer, Pablo E Morales, Matías Monsalves-Alvarez, Mariana Cifuentes, Beverly A Rothermel, Sergio Lavandero
  Endocrine Reviews.2020;[Epub]     CrossRef
• Inflammatory Signaling and Brown Fat Activity
  Farah Omran, Mark Christian
  Frontiers in Endocrinology.2020;[Epub]     CrossRef
• Omega-3 fatty acids as regulators of brown/beige adipose tissue: from mechanisms to therapeutic potential
  Marta Fernández-Galilea, Elisa Félix-Soriano, Ignacio Colón-Mesa, Xavier Escoté, Maria J. Moreno-Aliaga
  Journal of Physiology and Biochemistry.2020; 76(2): 251.     CrossRef
• Anti-Inflammatory Strategies Targeting Metaflammation in Type 2 Diabetes
  Alina Kuryłowicz, Krzysztof Koźniewski
  Molecules.2020; 25(9): 2224.     CrossRef
• Obese Adipose Tissue Secretion Induces Inflammation in Preadipocytes: Role of Toll-Like Receptor-4
  Mariana Renovato-Martins, Catharina Moreira-Nunes, Georgia C. Atella, Christina Barja-Fidalgo, João Alfredo de Moraes
  Nutrients.2020; 12(9): 2828.     CrossRef
• Diabetes and Metabolism Journal in 2020: Good to Great
  In-Kyung Jeong
  Diabetes & Metabolism Journal.2020; 44(1): 1.     CrossRef
• The Effect of Silibinin on Protein Expression Profile in White Adipose Tissue of Obese Mice
  Fei Wang, Shuchun Chen, Luping Ren, Yichao Wang, Zelin Li, Tiantian Song, He Zhang, Qiwen Yang
  Frontiers in Pharmacology.2020;[Epub]     CrossRef
• Beneficial Effects of Bariatric Surgery-Induced by Weight Loss on the Proteome of Abdominal Subcutaneous Adipose Tissue
  Bárbara María Varela-Rodríguez, Paula Juiz-Valiña, Luis Varela, Elena Outeiriño-Blanco, Susana Belén Bravo, María Jesús García-Brao, Enrique Mena, José Francisco Noguera, Javier Valero-Gasalla, Fernando Cordido, Susana Sangiao-Alvarellos
  Journal of Clinical Medicine.2020; 9(1): 213.     CrossRef
• Impact of Skeletal Muscle Mass on Metabolic Health
  Gyuri Kim, Jae Hyeon Kim
  Endocrinology and Metabolism.2020; 35(1): 1.     CrossRef
• Sea buckthorn (Hippophae rhamnoides L.) oil enhances proliferation, adipocytes differentiation and insulin sensitivity in 3T3-L1 cells
  Ting Zhang, Xuze Qin, Yuxin Cao, Jianxin Zhang, Junxing Zhao
  Food Science and Biotechnology.2020; 29(11): 1511.     CrossRef
• Adipose tissue secretory profile and cardiometabolic risk in obesity
  Pengcheng Zhang, Daniels Konja, Yu Wang
  Endocrine and Metabolic Science.2020; 1(3-4): 100061.     CrossRef
• Mitochondrial Dynamics in the Brain Are Associated With Feeding, Glucose Homeostasis, and Whole-Body Metabolism
  Jessica L. Haigh, Lauryn E. New, Beatrice M. Filippi
  Frontiers in Endocrinology.2020;[Epub]     CrossRef
• Adipogenesis: A Necessary but Harmful Strategy
  Mohammed El Hafidi, Mabel Buelna-Chontal, Fausto Sánchez-Muñoz, Roxana Carbó
  International Journal of Molecular Sciences.2019; 20(15): 3657.     CrossRef